RT Journal Article
T1 Synthetic Supramolecular Systems in Life-like Materials and Protocell Models
A1 Insua López, Ignacio
A1 Montenegro García, Javier
K1 Supramolecular chemistry
K1 Self-assembly
K1 Life-like materials
K1 Synthetic cells
K1 Biomimicry
K1 Protocells
AB One of the biggest challenges in modern chemistry is the preparation of synthetic materials with life-like behavior for the assembly of artificial cells. In recent years, numerous artificial systems that mimic cellular components and functions have been developed. Supramolecular chemistry plays a key role in such cell mimics given that non-covalent interactions control the shape and function of many biomolecules, such as DNA base pairing, protein structure, ligand-receptor binding, and lipid membrane packing. However, the complexity of living cells constitutes a major challenge for their bottom-up assembly from pure synthetic materials. Inspired by the building blocks of nature, a wide range of supramolecular systems have been developed to reproduce cellular functions such as cell-cell communication, signaling cascades, and dynamic cytoskeleton assemblies. This review surveys a selection of key advances in synthetic derivatives of biomolecules with supramolecular organization and life-like behavior by addressing their non-covalent foundation and integration as increasingly complex protocell models
PB Elsevier
SN 2451-9294
YR 2020
FD 2020
LK http://hdl.handle.net/10347/26916
UL http://hdl.handle.net/10347/26916
LA eng
NO I. Insua, J. Montenegro, Chem 2020, 6(7), 1652-1682
NO This work was partially supported by the Spanish Agencia Estatal de Investigación (AEI; SAF2017-89890-R), Xunta de Galicia (ED431C 2017/25, 2016-AD031, and ED431G/09), ISCIII (RD16/0008/003), and the European Commission (EC; European Regional Development Fund). I.I. thanks the EC and AEI for MSCA-IF (2018-843332) and JdC (FJCI-2017-31795) fellowships, respectively. J.M. received a Ramón y Cajal grant (RYC-2013-13784), an ERC-Stg grant (DYNAP-677786), and a Young Investigator Grant from the Human Frontier Science Program (RGY0066/2017)
DS Minerva
RD 25 abr 2026