RT Journal Article
T1 Development of inert coatings to prevent drug retention in 3D-printed diffusion cells
A1 Bendicho Lavilla, Carlos
A1 Díaz Tomé, Victoria
A1 Seoane Viaño, Iria
A1 Luzardo Álvarez, Asteria María
A1 Otero Espinar, Francisco Javier
K1 Stereolithography (SLA) 3D printing
K1 Drug retention
K1 Franz diffusion cells
K1 In vitro release tests
K1 Inert coatings
AB Diffusion cells play a crucial role in the pharmaceutical and cosmetic fields by assessing the release and permeation of active pharmaceutical ingredients across membranes. However, commercially available glass-based devices, such as Franz diffusion cells, are expensive and fragile. The emergence of three-dimensional (3D) printing technology enables the creation of diffusion cells with cost-effective polymeric materials and resins, offering exceptional precision and custom geometries. Nonetheless, there are challenges associated with interactions between 3D printing materials and drug molecules. This work aimed to develop inert coatings for 3D-printed diffusion models. Diffusion devices were designed and 3D-printed with a stereolithography (SLA) 3D printer, and different coatings were applied. Then, two model drugs were used to evaluate drug retention by coated devices. Among the tested coatings, one of them showed great potential in preventing drug retention and was selected for subsequent experiments with different drugs and conditions. Finally, voriconazole eyedrops were used to confirm the viability of 3D-printed Franz diffusion cells as a drug release diffusion model. The favourable results obtained with the coating promote the use of 3D printing as a cost-effective manufacturing technology, capable of producing diffusion cells tailored to specific study requirements
PB Elsevier
SN 0378-5173
YR 2024
FD 2024-05-23
LK http://hdl.handle.net/10347/34869
UL http://hdl.handle.net/10347/34869
LA eng
NO International Journal of Pharmaceutics 659 (2024) 124256
NO I.S.V. and V. D. T acknowledges Consellería de Cultura, Educación e Universidade for their Postdoctoral Fellowships (Xunta de Galicia, Spain; ED481B-2021-019 and ED481B-2023-092). Work supported by MICINN [PID2022- 142350OB-C21]. Authors would like to thank the use of RIAIDT-USC analytical facilities
DS Minerva
RD 23 abr 2026