RT Journal Article
T1 Retinoic Acid Profiles in Proliferative Verrucous versus Homogeneous Leukoplakia: A preliminary nested case–control study
A1 Chamorro Petronacci, Cintia Micaela
A1 Pérez Jardón, Alba
A1 Bravo López, Susana Belén
A1 Gándara Vila, Pilar
A1 Blanco Carrión, Andrés
A1 Avila Granizo, Yajaira Vanessa
A1 Lorenzo Pouso, Alejandro Ismael
A1 Prieto Barros, Sara Alexandra
A1 Pérez-Sayáns García, Mario
K1 Retinoic acid
K1 Mouth neoplasm
K1 Oral leukoplakia
K1 Proliferative verrucous leukoplakia
K1 Mass spectrometry
AB Background: Oral leukoplakia (OL) and proliferative verrucous leukoplakia (PVL) remain challenging entities due to the absence of reliable prognostic biomarkers. All-trans retinoic acid (atRA), a pivotal modulator of epithelial differentiation and mucosal integrity, has been proposed as a candidate biomarker. This study sought to quantify plasma RA levels in patients with OL and PVL compared to healthy controls, assessing their potential clinical utility. Methods: A cohort of 40 participants was recruited, comprising 10 patients with OL, 10 with PVL, and 20 healthy controls. This nested case–control study was derived from previously characterized institutional databases of oral potentially malignant disorders. Plasma samples were analyzed for atRA concentration using high-precision mass spectrometry. Statistical comparisons were conducted to evaluate differences between groups and associations with clinical outcomes. Results: Patients with homogeneous OL exhibited significantly reduced plasma atRA concentrations (mean 2.17 ± 0.39 pg/mL) relative to both PVL patients (2.64 ± 0.56 pg/mL) and healthy controls (2.66 ± 0.92 pg/mL), with p-values of 0.009 and 0.039, respectively. No statistically significant difference was found between PVL patients and controls. Furthermore, atRA levels demonstrated no correlation with clinicopathological variables or malignant progression within the PVL cohort. Conclusions: These preliminary findings indicate that diminished plasma atRA levels may serve as a prognostic marker for homogeneous oral leukoplakia, whilst its role in PVL appears limited. However, effect estimates were imprecise, and additional studies are warranted.
PB Multidisciplinary Digital Publishing Institute MDPI
SN 2227-9059
YR 2025
FD 2025-08-02
LK https://hdl.handle.net/10347/44249
UL https://hdl.handle.net/10347/44249
LA eng
NO Chamorro-Petronacci, C. M., Pérez-Jardón, A., Bravo, S. B., Gándara-Vila, P., Blanco-Carrión, A., Avila-Granizo, Y. V., Lorenzo-Pouso, A. I., Prieto-Barros, S. A., & Pérez-Sayáns, M. (2025). Retinoic Acid Profiles in Proliferative Verrucous Versus Homogeneous Leukoplakia: A Preliminary Nested Case–Control Study. Biomedicines, 13(8), 1881. https://doi.org/10.3390/biomedicines13081881
DS Minerva
RD 23 abr 2026