RT Journal Article
T1 Chain-branched polyhydroxylated Octahydro-1H-Indoles as potential leads against lysosomal storage diseases
A1 Estévez Cabanas, Juan Carlos
A1 González, Marcos A.
A1 Villaverde Cameron-Walker, María del Carmen
A1 Hirokami, Yuki
A1 Kato, Atsushi
A1 Sussman, Fredy Salomon
A1 Reza Ramos, David
A1 Estévez Cabanas, Ramón José
K1 Sugars
K1 Iminosugars
K1 Glycosidase inhibition
AB Here, the synthesis and glycosidase inhibition properties of the two first known 3-ethyloctahydro-1H-indole-4,5,6-triols are reported. This study shows the transformation of d-glucose into polyhydroxylated 1-(2-nitrocyclohexane) acetaldehydes, followed by a protocol involving the formation of the azacyclopentane ring. Results of inhibitory potency assays and docking calculations show that at least one of them could be a lead for optimization in the search for compounds that behave like folding chaperones in lysosomal storage diseases
PB MDPI
YR 2019
FD 2019
LK http://hdl.handle.net/10347/21304
UL http://hdl.handle.net/10347/21304
LA eng
NO Estévez, J.C.; González, M.A.; Villaverde, M.C.; Hirokami, Y.; Kato, A.; Sussman, F.; Reza, D.; Estévez, R.J. Chain-Branched Polyhydroxylated Octahydro-1H-Indoles as Potential Leads against Lysosomal Storage Diseases. Pharmaceuticals 2019, 12, 47
NO This work has received financial support from the Spanish Ministry of Science and Innovation(CTQ2009-08490), the Xunta de Galicia (Centro Singular de Investigación de Galicia, accreditation 2016–2019,ED431B 2018/13; Project CN2011/037 and Project GRC2014/040), and the European Union (European RegionalDevelopment Fund-ERDF). It has also received a Grant-in-Aid for Scientific Research (C) from the Japanese Societyfor the Promotion of Science (JSPS KAKENHI Grant Number JP17K08362) (AK)
DS Minerva
RD 24 abr 2026