RT Journal Article
T1 Determination and diagnostic value of CA9 mRNA in peripheral blood of patients with oral leukoplakia
A1 Torres López, Manuel
A1 Pérez-Sayáns García, Mario
A1 Chamorro Petronacci, Cintia
A1 Barros Angueira, Francisco
A1 Gándara Vila, Pilar
A1 Lorenzo Pouso, Alejandro
A1 García García, Abel
K1 CA9
K1 Oral squamous cell carcinoma
K1 Leukoplakia
AB Background: Oral leukoplakia is one of the most common oral premalignant disorder. The classical evaluation through tissue biopsy is not always valid to evaluate the risk of malignization.Material and methods: RT-qPCR was performed on 47 blood samples (21 patients with leukoplakia, 2 with oral squamous cell carcinoma (OSCC), and 24 healthy patients) and on 11 tissue samples (3 leukoplakia, 4 OSCC, and 4 samples of healthy tissue).Results: There are significant differences in expression between the different groups (F = 4.057, p = .006). The Duncan post hoc test shows that the only group that differentiates is the tumour tissue. Using Wilcoxon test, different covariables of patients with leukoplakia were analysed with respect to the group of healthy patients and no significant differences were observed.Conclusions: The diagnostic route through liquid biopsy has not been conclusive in this study, but there are significant differences in the levels analysed in the different tissue samples.
PB Taylor & Francis
SN 1475-6366
YR 2018
FD 2018-12
LK https://hdl.handle.net/10347/46981
UL https://hdl.handle.net/10347/46981
LA eng
NO Torres López, M., Pérez Sayáns, M., Chamorro Petronacci, C., Barros Angueira, F., Gándara Vila, P., Lorenzo Pouso, A., & García García, A. (2018). Determination and diagnostic value of CA9 mRNA in peripheral blood of patients with oral leukoplakia. Journal of Enzyme Inhibition and Medicinal Chemistry, 33(1), 951–955. https://doi.org/10.1080/14756366.2018.1466120
DS Minerva
RD 23 may 2026