RT Journal Article
T1 The polymorphism Val158Met in the COMT gene: disrupted dopamine system in fibromyalgia patients?
A1 Gerra, María Carla
A1 Dallabona, Cristina
A1 Manfredini, Matteo
A1 Giordano, Rocco
A1 Capriotti, Camilla
A1 González Villar, Alberto Jacobo
A1 Triñanes Pego, Yolanda
A1 Arendt Nielsen, Lars
A1 Carrillo de la Peña, María Teresa
K1 Val158Met
K1 Fibromyalgia
K1 COMT
K1 Dopamine
K1 Pain intensity
K1 Fibromyalgia comorbidities
AB The single-nucleotide polymorphism (SNP) rs4680 in the catechol-O-methyltransferase gene (COMT) is a missense variant (Val158Met) associated with altered activity of the COMT enzyme and suggested as a predictive feature for developing some chronic pain conditions. However, there are controversial results on its role in fibromyalgia (FM). Here, the SNP Val158Met was analyzed in 294 FM patients (without comorbidities) and 209 healthy controls (without chronic pain). The concurrent impact of Val158Met genotypes and FM comorbid disorders (depression and sleep impairment) on FM risk were tested. In addition, the genotypic distribution of FM patients in relation to pain intensity was evaluated. The G allele (Val) resulted in being more represented in the FM group (57.8%) compared with the control group (48.8%; P = 0.037). Logistic regression highlighted that having the G/G (Val/Val) homozygous genotype was associated with 2 times higher risk of having FM compared with the A/A (Met/Met) carriers (P = 0.038), whereas depression and sleep impairment increased FM risk by 12 and 8 times, respectively (P < 0.001). However, considering only the FM patient group, the A/A homozygous genotype was significantly associated with severe pain intensity (P = 0.007). This study highlighted associations between the SNP Val158Met and both FM and pain intensity, suggesting a link between dopaminergic dysfunction and vulnerability to chronic pain. Further studies should explore this SNP in FM patients in conjunction with COMT enzymatic activity and other symptoms connected with the dopaminergic system such as depression or sleep impairment
PB Lippincott Williams & Wilkins
YR 2024
FD 2024-12
LK https://hdl.handle.net/10347/45467
UL https://hdl.handle.net/10347/45467
LA eng
NO Gerra, M. C., Dallabona, C., Manfredini, M., Giordano, R., Capriotti, C., González-Villar, A., Triñanes, Y., Arendt-Nielsen, L., & Carrillo-De-La-Peña, M. T. (2024). The polymorphism Val158Met in the COMT gene: disrupted dopamine system in fibromyalgia patients? Pain, 165(12), e184-e189. https://doi.org/10.1097/J.PAIN.0000000000003313
NO This study was supported by Spanish Government Funding (Ministerio de Economía y Competitividad: grant PSI2013-45818-R). M.C.G. is supported by a fixed-term research assistant contract by the COMP-HUB Initiative, funded by the “Departments of Excellence” program of the Italian Ministry for Education, University and Research (MIUR, 2018-2022). L.A.N. and R.G. are part of the Center for Neuroplasticity and Pain (CNAP) that is supported by the Danish National Research Foundation (DNRF121) and The Danish Rheumatism Association
DS Minerva
RD 23 abr 2026