RT Journal Article
T1 3D printed carboxymethyl cellulose scaffolds for autologous growth factors delivery in wound healing
A1 Díaz Gómez, Luis
A1 González Prada, Iago
A1 Millán Lence, Rosendo
A1 Silva Candal, Andrés da
A1 Bugallo Casal, Ana
A1 Campos Pérez, Francisco
A1 Concheiro Nine, Ángel Joaquín
A1 Álvarez Lorenzo, Carmen
K1 Carboxymethyl cellulose
K1 3D printing
K1 Rheological properties
K1 MicroCT
K1 Platelet rich plasma
K1 Wound healing
K1 Cell mobility
K1 Angiogenesis
AB This work aims to use carboxymethyl cellulose (CMC) as main structural and functional component of 3D printed scaffolds for healing of diabetic wounds. Differently from previous inks involving small contents in CMC, herein sterile (steam-heated) concentrated CMC solely dispersions (10–20%w/v) were screened regarding printability and fidelity properties. CMC (15%w/v)-citric acid inks showed excellent self-healing rheological properties and stability during storage. CMC scaffolds loaded with platelet rich plasma (PRP) sustained the release of relevant growth factors. CMC scaffolds both with and without PRP promoted angiogenesis in ovo, stem cell migration in vitro, and wound healing in a diabetic model in vivo. Transparent CMC scaffolds allowed direct monitoring of bilateral full-thickness wounds created in rat dorsum. CMC scaffolds facilitated re-epithelialization, granulation, and angiogenesis in full-thickness skin defects, and the performance was improved when combined with PRP. Overall, CMC is pointed out as outstanding component of active dressings for diabetic wounds
PB Elsevier
YR 2022
FD 2022
LK http://hdl.handle.net/10347/27437
UL http://hdl.handle.net/10347/27437
LA eng
NO Carbohydrate Polymers 278 (2022) 118924
DS Minerva
RD 28 abr 2026