RT Journal Article
T1 Melatonin-eluting contact lenses effect on tear volume: In Vitro and In Vivo experiments
A1 Serramito Blanco, María
A1 Mota, Ana F. Pereira da
A1 Carpena Torres, Carlos
A1 Huete Toral, Fernando
A1 Álvarez Lorenzo, Carmen
A1 Carracedo Rodríguez, Juan Gonzalo
K1 Melatonin
K1 Contact lenses
K1 Drug delivery
K1 Dry eye
K1 Glaucoma
AB (1) Background: The purpose of this study was to synthesize melatonin-eluting contact lenses (CLs) and evaluate both the ocular kinetics of the released melatonin and its effect on tear volume and intraocular pressure. (2) Methods: In vitro, melatonin-eluting CLs were synthesized by using non-functionalized (HEMA) and functionalized (HEMA/APMA) monomers. In vivo, a short-term prospective and randomized study was performed on 15 rabbits divided into two groups: 12 rabbits wearing functionalized CLs and 3 rabbits without CLs as a control. The melatonin levels in tears, aqueous humor, vitreous body and retina, tear volume, and intraocular pressure were measured for 8 h. (3) Results: In vitro, both monomers did not show differences in terms of melatonin loading and release (p ≥ 0.05). In vivo, the melatonin concentration was elevated in tears and aqueous humor after 2 and 4 h of wearing CLs, respectively (p < 0.05). Additionally, the CLs increased tear volume for 2 h (p < 0.05). (4) Conclusions: The melatonin-eluting CLs released their content over the ocular surface for at least 2 h, which was associated with a secretagogue effect on tear volume. However, the increased amount of melatonin found in the aqueous humor had no effect on intraocular pressure
PB MDPI
SN 1999-4923
YR 2022
FD 2022
LK http://hdl.handle.net/10347/30386
UL http://hdl.handle.net/10347/30386
LA eng
NO Pharmaceutics 2022, 14(5), 1019
NO The work was partially supported by the European Union’s Horizon 2020 research and innovation programme under the Marie-Skłodowska-Curie Actions grant agreement N◦ 813440 (ORBITAL-Ocular Research by Integrated Training and Learning)
DS Minerva
RD 30 abr 2026