RT Dissertation/Thesis
T1 Bioconjugation of proteins to nanoparticles for the development of advanced therapies
A1 Abal Sanisidro, Marcelina
K1 Nanoparticles
K1 proteins
K1 gene therapy
K1 pancreatic cancer
K1 photodynamic therapy
AB Proteins are biomacromolecules that catalyze multiplebiological processes, being promising therapeutic agents.However, issues such as enzymatic degradation, short half-lifeand low bioavailability make their use in the clinicinefficient. In this respect, nanotechnology arises as a potenttool to overcome these limitations, offering protection ofcargo, increased bioavailability and reduced immunogenicity.Within this frame, the main aim of this thesis is thedevelopment of novel protein nanotherapeutics by exploringseveral bioconjugation strategies, providing evidence of theirbenefits in cancer therapy and gene editing. Altogether, thisthesis sheds light on the potential of a versatile nanoplatformfor protein delivery as translational medicines and open thedoor for further application in advanced therapies.
YR 2024
FD 2024
LK http://hdl.handle.net/10347/34453
UL http://hdl.handle.net/10347/34453
LA eng
DS Minerva
RD 3 may 2026