RT Journal Article
T1 Glucagon, GLP-1 and thermogenesis
A1 González García, Ismael
A1 Milbank, Edward
A1 Diéguez González, Carlos
A1 López Pérez, Miguel A.
A1 Contreras, Cristina
K1 Glucagon
K1 GLP1
K1 Thermogenesis
K1 Brown adipose tissue
K1 Browning
K1 Hypothalamic control of energy balance
AB Brown adipose tissue (BAT) thermogenesis is a conserved mechanism to maintain body temperature in mammals. However, since BAT contribution to energy expenditure can represent a relevant modulator of metabolic homeostasis, many studies have focused on the nervous system and endocrine factors that control the activity of this tissue. There is long-established evidence that the counter-regulatory hormone glucagon negatively influences energy balance, enhances satiety, and increases energy expenditure. Despite compelling evidence showing that glucagon has direct action on BAT thermogenesis, recent findings are questioning this conventional attribute of glucagon action. Glucagon like peptide-1 (GLP-1) is an incretin secreted by the intestinal tract which strongly decreases feeding, and, furthermore, improves metabolic parameters associated with obesity and diabetes. Therefore, GLP-1 receptors (GLP-1-R) have emerged as a promising target in the treatment of metabolic disorders. In this short review, we will summarize the latest evidence in this regard, as well as the current therapeutic glucagon- and GLP-1-based approaches to treating obesity.
PB MDPI
SN 1661-6596
YR 2019
FD 2019
LK http://hdl.handle.net/10347/21474
UL http://hdl.handle.net/10347/21474
LA eng
NO González-García, I.; Milbank, E.; Diéguez, C.; López, M.; Contreras, C. Glucagon, GLP-1 and Thermogenesis. Int. J. Mol. Sci. 2019, 20, 3445.
NO This research was funded by Xunta de Galicia (ML: 2015-CP079; CD: BFU2017-87721), MINECO co-funded by the FEDER Program of EU (ML: SAF2015-71026-R and BFU2015-70454-REDT/Adipoplast) and Atresmedia. CIBER de Fisiopatología de la Obesidad y Nutrición is an initiative of ISCIII
DS Minerva
RD 29 abr 2026