RT Journal Article
T1 Evolution of Resistance in Poultry Intestinal Escherichia coli During Three Commonly Used Antimicrobial Therapeutic Treatments in Poultry
A1 Miranda López, José Manuel
A1 Vázquez Belda, Beatriz Isabel
A1 Fente Sampayo, Cristina Asunción
A1 Barros Velázquez, Jorge
A1 Cepeda Sáez, Alberto
A1 Franco Abuín, Carlos Manuel
K1 Escherichia coli
K1 Poultry
K1 Resistance
K1 Antimicrobial
K1 Treatment
AB The resistance rates of intestinal Escherichia coli populations from poultry were determined during treatment and withdrawal period with 3 antimicrobial agents commonly used as therapeutics in poultry medicine. A total of 108 chickens were considered: 18 were treated orally with enrofloxacin, 18 with doxycycline, and 18 with sulfonamides, whereas another 18 chickens were maintained as controls for each antimicrobial group. Fecal samples were taken during the treatment and after the withdrawal period, and E. coli were isolated through Fluorocult media plating. A total of 648 E. coli strains (216 per antimicrobial tested) were isolated and identified though biochemical methods. Minimal inhibitory concentrations to the antimicrobials used were also determined using a broth microdilution method. The resistance rates of intestinal E. coli to all of the antimicrobials tested significantly increased during the course of the therapeutic treatment. In addition, significant differences (P = 0.0136) in resistance rates persisted between the intestinal E. coli of the enrofloxacin-treated and control batches until the end of the withdrawal period, but this difference was not observed for the cases of doxycycline or sulfonamides treatments. Antimicrobial use in poultry medicine seems to select for antimicrobial-resistant strains of pathogenic bacterial species such as E. coli. In some cases, the higher frequencies of resistant strains may persist in the avian intestinal tract until the end of the withdrawal period, when it is legal to use these animals for human consumption
PB Elsevier
SN 0032-5791
YR 2008
FD 2008
LK http://hdl.handle.net/10347/24264
UL http://hdl.handle.net/10347/24264
LA eng
NO Poultry Science, Volume 87, Issue 8, 1 August 2008, Pages 1643-1648
NO The authors wish to thank the Xunta de Galicia for granting research project (PGIDIT05TAL003E)
DS Minerva
RD 27 abr 2026