RT Journal Article
T1 Effects of recombinant growth hormone (GH) replacement and psychomotor and cognitive stimulation in the neurodevelopment of GH-deficient (GHD) children with cerebral palsy: a pilot study
A1 Devesa Múgica, Jesús
A1 Alonso, Begoña
A1 Casteleiro, Nerea
A1 Couto, Paula
A1 Castañón, Beatriz
A1 Zas, Eva
A1 Reimunde Figueira, Pedro Marcos
K1 Growth hormone
K1 Cerebral palsy
K1 Cognitive functions
K1 Battelle’s test
K1 Neurodevelopment
AB Cerebral palsy (CP) is the main cause of physical disability in childhood and is an important health issue that has a strong socioeconomic impact. There is no effective treatment for CP and therapeutic approaches report only partial benefits for affected people. In this study we assessed the effects of growth hormone (GH) treatment combined with psychomotor and cognitive stimulation in the neurodevelopment of children with CP and GH deficiency (GHD). The study was carried out in 11 patients (7 boys and 4 girls; 4.12 ± 1.31 years) with GHD and CP who were treated with recombinant GH (rGH) and psychomotor and cognitive stimulation during 2 months. Battelle Developmental Inventory Screening Test (BDIST) was performed 2 months before commencing GH treatment, just before commencing GH administration, and after 2 months of combined treatment involving GH and cognitive stimulation. Psychomotor and cognitive status did not change during the period in which only cognitive stimulation was performed; however, significant improvements in personal and social skills, adaptive behavior, gross motor skills and total psychomotor abilities, receptive and total communication, cognitive skills and in the total score of the test (P < 0.01), and in fine motor skills and expressive communication (P < 0.02) were observed after the combined treatment period. Therefore, GH replacement together with psychomotor and cognitive stimulation seem to be useful for the appropriate neurodevelopment of children with GHD and CP.
PB Dove Medical Press
YR 2011
FD 2011
LK http://hdl.handle.net/10347/21569
UL http://hdl.handle.net/10347/21569
LA eng
NO Devesa J, Alonso, Casteleiro, Couto, Castanón, Zas, Reimunde. Effects of recombinant growth hormone (GH) replacement and psychomotor and cognitive stimulation in the neurodevelopment of GH-deficient (GHD) children with cerebral palsy: a pilot study. Ther Clin Risk Manag. 2011;7:199-206. https://doi.org/10.2147/TCRM.S21403
NO This study was supported by Fundación Foltra and Fundación Repsol
DS Minerva
RD 3 may 2026