RT Dissertation/Thesis
T1 Novel approaches for the discovery of pharmacogenetic biomarkers of chemotoxicity in patients with colorectal cancer
A1 Simões, Ana Rita Santos
K1 colorectal cancer
K1 adverse drug reactions
K1 pharmacogenetics
K1 pharmacogenomics
K1 personalised medicine
AB Colorectal cancer (CRC) is often linked to adverse drugreactions (ADRs), which can be severe or even fatal. To addressthis issue, pharmacogenetic studies have emerged to helppersonalise treatments based on molecular information.However, these have been limited by a lack of standardizeddata, the complexity of ADR phenotyping and the need fornovel strategies and functional assays. Therefore, the aim ofthis project was to find and validate new CRC chemotoxicitybiomarkers, using state-of-the-art approaches. We haveconducted different omic analyses to identify low to highpenetrancevariants and performed in vitro assays on a variantof interest. Our work successfully identified severalcandidate toxicity variants/genes that might be influencing thedevelopment of ADRs in CRC patients.
YR 2023
FD 2023
LK http://hdl.handle.net/10347/31305
UL http://hdl.handle.net/10347/31305
LA eng
DS Minerva
RD 28 abr 2026