RT Journal Article
T1 Unraveling the Role of Leptin in Liver Function and Its Relationship with Liver Diseases
A1 Martínez Uña, Maite
A1 López Mancheño, Yaiza
A1 Diéguez González, Carlos
A1 Fernández Rojo, Manuel A.
A1 Garrido Novelle, Marta
K1 Leptin
K1 Adipose tissue
K1 Non-alcoholic fatty liver disease (NAFLD)
K1 Non-alcoholic steatohepatitis (NASH)
K1 Hepatocarcinoma (HCC)
K1 Partial hepatectomy
K1 Liver regeneration
AB Since its discovery twenty-five years ago, the fat-derived hormone leptin has provided a revolutionary framework for studying the physiological role of adipose tissue as an endocrine organ. Leptin exerts pleiotropic effects on many metabolic pathways and is tightly connected with the liver, the major player in systemic metabolism. As a consequence, understanding the metabolic and hormonal interplay between the liver and adipose tissue could provide us with new therapeutic targets for some chronic liver diseases, an increasing problem worldwide. In this review, we assess relevant literature regarding the main metabolic effects of leptin on the liver, by direct regulation or through the central nervous system (CNS). We draw special attention to the contribution of leptin to the non-alcoholic fatty liver disease (NAFLD) pathogenesis and its progression to more advanced stages of the disease as non-alcoholic steatohepatitis (NASH). Likewise, we describe the contribution of leptin to the liver regeneration process after partial hepatectomy, the mainstay of treatment for certain hepatic malignant tumors
PB MDPI
YR 2020
FD 2020
LK http://hdl.handle.net/10347/24068
UL http://hdl.handle.net/10347/24068
LA eng
NO Martínez-Uña, M.; López-Mancheño, Y.; Diéguez, C.; Fernández-Rojo, M.A.; Novelle, M.G. Unraveling the Role of Leptin in Liver Function and Its Relationship with Liver Diseases. Int. J. Mol. Sci. 2020, 21, 9368
NO M.G.N. is recipient of “Juan de la Cierva-Incorporación” fellowship (IJCI-2017-32606) from Ministeriode Ciencia, Innovación y Universidades, Spain. This work was supported by grants from FEDER/Ministerio deCiencia, Innovación y Universidades-Agencia Estatal de Investigación (CD: BFU2017-87721) and the TALENTOProgram from the Madrid Government (MAFR 2016/T1- BIO-1854). Financial support from the Xunta de Galicia(Centro singular de investigación de Galicia accreditation 2019-2022- ED431G 2019/02) and the European Union(European Regional Development Fund—ERDF), is gratefully acknowledged. Centro de Investigación Biomédicaen Red (CIBER) de Fisiopatología de la Obesidad y Nutrición (CIBERobn) is an initiative of the Instituto de SaludCarlos III (ISCIII) of Spain, which is supported by FEDER funds (EU)
DS Minerva
RD 29 abr 2026