RT Journal Article T1 Investigating the Dietary Impact on Trans-Vaccenic Acid (Trans-C18:1 n-7) and Other Beneficial Fatty Acids in Breast Milk and Infant Formulas A1 Sanjulián Fernández, Laura A1 Lamas Freire, Alexandre A1 Barreiro Tomé, Rocío A1 Martínez, Ismael A1 García Alonso, Leopoldo A1 Cepeda Sáez, Alberto A1 Fente Sampayo, Cristina Asunción A1 Regal López, Patricia K1 Breast milk K1 Human milk K1 SEAD K1 Atlantic diet K1 Trans-vaccenic acid K1 Trans fatty acid AB Maternal diet plays a significant role in the fatty acid composition of breast milk. Dietary products such as milk and meat are the primary sources of natural TFAs for humans. These peculiar fatty acids hold nutritional significance as they not only lack the detrimental effects of industrially produced trans fats on the endothelium characteristic, but they also exhibit anti-inflammatory properties. The relationship between the presence of eight fatty acids in breast milk (including natural TFAs trans-vaccenic and conjugated linoleic acid) and the maternal diet has been explored, and their abundance has been compared to that of infant formulas. Two cohorts of lactating women, originating from a Spanish region, participated in this study; they adhered to the Southern European Atlantic diet or the Atlantic diet. While the consumption of conventional meat or dairy products does not seem to increase the abundance of TFAs in breast milk, trans-vaccenic and oleic acid are among the most distinctive features of breast milk fat in mothers consuming naturally improved dairy products with an improved fatty acid profile. The most significant differences between natural breastfeeding and formula feeding lie in natural TFAs, since formulas are notably deficient in natural TFAs while being overfortified in alpha-linolenic acid in comparison to breast milk. We suggest an improvement in the formulation of these products through using cow’s milk with an optimal fatty acid profile that better mimics the fatty acid composition found in human milk. PB MDPI SN 2304-8158 YR 2024 FD 2024-07-09 LK https://hdl.handle.net/10347/43402 UL https://hdl.handle.net/10347/43402 LA eng NO Sanjulian, L.; Lamas, A.; Barreiro, R.; Martínez, I.; García- Alonso, L.; Cepeda, A.; Fente, C.; Regal, P. Investigating the Dietary Impact on Trans-Vaccenic Acid (Trans-C18:1 n-7) and Other Beneficial Fatty Acids in Breast Milk and Infant Formulas. Foods 2024, 13, 2164. https://doi.org/10.3390/ foods13142164 NO Xunta de Galicia and European Regional Development Funds (FEDER): consolidation grant ED431C 2022/14 DS Minerva RD 28 abr 2026