RT Journal Article
T1 Dissecting the proton transport pathway in oral squamous cell carcinoma: state of the art and theranostics implications
A1 Lorenzo Pouso, Alejandro Ismael
A1 Pérez-Sayáns García, Mario
A1 Rodríguez Zorrilla, Samuel
A1 Chamorro Petronacci, Cintia Micaela
A1 García García, Abel
K1 Mouth neoplasm
K1 Carbonic anhydrases
K1 Monocarboxy late transporters
K1 Na+/H+ exchanger
K1 V-ATPase
AB Cancer cells overexpress proton exchangers at the plasma membrane in order acidify the extracellular matrix and maintain the optimal pH for sustaining cancer growth. Among the families of proton exchangers implicated in carcinogenesis, carbonic anhydrases (CAs), monocarboxylate transporters (MCTs), Na+/H+ exchangers (NHEs), sodium bicarbonate cotransporters (NBCs), and vacuolar ATPases (V-ATPases) are highlighted. Considerable research has been carried out into the utility of the understanding of these machineries in the diagnosis and prognosis of several solid tumors. In addition, as therapeutic targets, the interference of their functions has contributed to the discovery or optimization of cancer therapies. According to recent reports, the study of these mechanisms seems promising in the particular case of oral squamous cell carcinoma (OSCC). In the present review, the latest advances in these fields are summarized, in particular, the usefulness of proton exchangers as potential prognostic biomarkers and therapeutic targets in OSCC
PB MDPI
YR 2019
FD 2019
LK http://hdl.handle.net/10347/21253
UL http://hdl.handle.net/10347/21253
LA eng
NO Lorenzo-Pouso, A.I.; Pérez-Sayáns, M.; Rodríguez-Zorrilla, S.; Chamorro-Petronacci, C.; García-García, A. Dissecting the Proton Transport Pathway in Oral Squamous Cell Carcinoma: State of the Art and Theranostics Implications. Int. J. Mol. Sci. 2019, 20, 4222
DS Minerva
RD 4 may 2026