RT Journal Article
T1 Validity and reliability of transbronchial needle aspiration for diagnosing mediastinal adenopathies
A1 Fernández Villar, Alberto
A1 Botana Rial, María Isabel
A1 Leiro Fernández, Virginia
A1 González, Ana
A1 Represas Represas, Cristina
A1 Ruano Raviña, Alberto
K1 Positive Predictive Value
K1 Sarcoidosis
K1 Negative Predictive Value
K1 Small Cell Lung Carcinoma
K1 Indirect Sign
AB BackgroundThe aim is to assess the validity and reliability of transbronchial needle aspiration (TBNA) of mediastinal and hilar adenopathies and to evaluate factors predictive of TBNA outcome.MethodsWe performed an analysis of prospectively collected data of patients (n = 580) who underwent TBNA (n = 685) from January 1998 to December 2007 in our center. Validity and reliability were evaluated for the overall sample and according to specific pathology. Factors predicting the successful acquisition of diagnostic samples were analyzed by multivariate analysis.ResultsOverall sensitivity, specificity, accuracy, and positive and negative predictive (NPV) values for TBNA were 68%, 100%, 68.8%, 100%, and 10%, respectively. The most sensitive and accurate TBNAs were obtained for patients with small cell lung carcinoma and the worst results were for patients with lymphomas. NPV were similar for all pathologies. The most predictive factors of outcome were adenopathy size and the presence of indirect signs at the puncture site.ConclusionThe sensitivity and accuracy of TBNA are high in small cell lung cancer, followed by other types of carcinoma, sarcoidosis, and tuberculosis, and low for lymphoproliferative diseases. The NPV of TBNA for all individual pathologies is low. The size of the adenopathy and the presence of indirect signs at the puncture site predict the achievement of diagnostic samples
PB BMC
SN 1471-2466
YR 2010
FD 2010
LK http://hdl.handle.net/10347/22951
UL http://hdl.handle.net/10347/22951
LA eng
NO Fernández-Villar, A., Botana, M., Leiro, V. et al. Validity and reliability of transbronchial needle aspiration for diagnosing mediastinal adenopathies. BMC Pulm Med 10, 24 (2010). https://doi.org/10.1186/1471-2466-10-24
NO Partially supported by a Research Intensification Activity from Fondo de Investigación Sanitaria (FIS)
DS Minerva
RD 3 may 2026