RT Journal Article
T1 Advances in lanthanide‐based luminescent peptide probes for monitoring the activity of kinase and phosphatase
A1 Pazos Chantrero, Elena
A1 Vázquez Sentís, Marco Eugenio
K1 Fluorescent assays
K1 Kinase sensing
K1 Luminescence
K1 Phosphatase sensing
K1 Sensors
AB Signaling pathways based on protein phosphorylation and dephosphorylation play critical roles in the orchestration of complex biochemical events and form the core of most signaling pathways in cells (i.e. cell cycle regulation, cell motility, apoptosis, etc.). The understanding of these complex signaling networks is based largely on the biochemical study of their components, i.e. kinases and phosphatases. The development of luminescent sensors for monitoring kinase and phosphatase activity is therefore an active field of research. Examples in the literature usually rely on the modulation of the fluorescence emission of organic fluorophores. However, given the exceptional photophysical properties of lanthanide ions, there is an increased interest in their application as emissive species for monitoring kinase and phosphatase activity. This review summarizes the advances in the development of lanthanide‐based luminescent peptide sensors as tools for the study of kinases and phosphatases and provides a critical description of current examples and synthetic approaches to understand these lanthanide‐based luminescent peptide sensors
PB Wiley
SN 1860-6768
YR 2014
FD 2014
LK http://hdl.handle.net/10347/18203
UL http://hdl.handle.net/10347/18203
LA eng
NO Pazos, E. and Vázquez, M. E. (2014), Advances in lanthanide‐based luminescent peptide probes for monitoring the activity of kinase and phosphatase. Biotechnology Journal, 9: 241-252. doi:10.1002/biot.201300203
NO This is the peer reviewed version of the following article: Pazos, E. and Vázquez, M. E. (2014), Advances in lanthanide‐based luminescent peptide probes for monitoring the activity of kinase and phosphatase. Biotechnology Journal, 9: 241-252. doi:10.1002/biot.201300203, which has been published in final form at https://doi.org/10.1002/biot.201300203. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions
NO We thank the support of the Spanish government’s grants SAF2010-20822-C02,  CTQ2012-31341,  CTQ2009-14431,SAF2007-61015   and   the   Xunta   de   Galicia   INCITE09   209  084PR,  GRC2010/12,  PGIDIT08CSA-047209PR.  E.P.thanks the Fundación Barrié de la Maza for her postdoc-toral fellowship
DS Minerva
RD 24 abr 2026