RT Journal Article
T1 Natural Products for Neurodegeneration: Regulating Neurotrophic Signals
A1 Uddin, Sahab
A1 Al Mamun, Abdullah
A1 Rahman, Motiar
A1 Jeandet, Philippe
A1 Alexiou, Athanasios
A1 Behl, Tapan
A1 Sarwar, Shahid
A1 Sobarzo Sánchez, Eduardo Marcelo
A1 Ashraf, Ghulam
A1 Sayed, Amany
A1 Albadrani, Ghadeer Mohsen
A1 Peluso, Ilaria
A1 Abdel-Daim, Mohamed
AB Neurodegenerative disorders (NDs) are heterogeneous groups of ailments typically characterized by progressive damage of the nervous system. Several drugs are used to treat NDs but they have only symptomatic benefits with various side effects. Numerous researches have been performed to prove the advantages of phytochemicals for the treatment of NDs. Furthermore, phytochemicals such as polyphenols might play a pivotal role in rescue from neurodegeneration due to their various effects as anti-inflammatory, antioxidative, and antiamyloidogenic agents by controlling apoptotic factors, neurotrophic factors (NTFs), free radical scavenging system, and mitochondrial stress. On the other hand, neurotrophins (NTs) including nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), NT4/5, and NT3 might have a crucial neuroprotective role, and their diminution triggers the development of the NDs. Polyphenols can interfere directly with intracellular signaling molecules to alter brain activity. Several natural products also improve the biosynthesis of endogenous genes encoding antiapoptotic Bcl-2 as well as NTFs such as glial cell and brain-derived NTFs. Various epidemiological studies have demonstrated that the initiation of these genes could play an essential role in the neuroprotective function of dietary compounds. Hence, targeting NTs might represent a promising approach for the management of NDs. In this review, we focus on the natural product-mediated neurotrophic signal-modulating cascades, which are involved in the neuroprotective effects
PB Hindawi
SN 1942-0900
YR 2021
FD 2021
LK http://hdl.handle.net/10347/26691
UL http://hdl.handle.net/10347/26691
LA eng
NO Oxidative Medicine and Cellular Longevity, 2021, 8820406, https://doi.org/10.1155/2021/8820406
NO This work was funded by the Deanship of Scientific Research at Princess Nourah bint Abdulrahman University through the Fast-track Research Funding Program
DS Minerva
RD 23 abr 2026