RT Journal Article
T1 Crosslinked Hyaluronan Electrospun Nanofibers for Ferulic Acid Ocular Delivery
A1 Grimaudo, Maria Aurora
A1 Concheiro Nine, Ángel Joaquín
A1 Álvarez Lorenzo, Carmen
K1 Ocular inserts
K1 Electrospinning
K1 Hyaluronan
K1 Ferulic acid
K1 ε-polylysine
K1 Nanofibers
AB Electrospun nanofibers are gaining interest as ocular drug delivery platforms that may adapt to the eye surface and provide sustained release. The aim of this work was to design an innovative ophthalmic insert composed of hyaluronan (HA) nanofibers for the dual delivery of an antioxidant (ferulic acid, FA) and an antimicrobial peptide (ε-polylysine, ε-PL). Polyvinylpyrrolidone (PVP) was added to facilitate the electrospinning process. Fibers with diameters of approx. 100 nm were obtained with PVP 5%-HA 0.8% w/v and PVP 10%-HA 0.5% w/v mixtures in ethanol:water 4:6 v/v. An increase in PVP concentration to 20% w/v in both presence and absence of HA rendered fibers of approx. 1 µm. PVP 5%-HA 0.8% w/v fibers were loaded with 83.3 ± 14.0 µg FA per mg. After nanofibers crosslinking with ε-PL, blank and FA-loaded inserts showed a mean thickness of 270 ± 21 µm and 273 ± 41 µm, respectively. Blank and FA-loaded inserts completely released ε-PL within 30 min under sink conditions, whereas FA-loaded inserts released the antioxidant within 20 min. Both blank and FA-loaded inserts were challenged against Pseudomonas aeruginosa and Staphylococcus aureus, demonstrating their efficacy against relevant microbial species
PB MDPI
YR 2020
FD 2020
LK http://hdl.handle.net/10347/23781
UL http://hdl.handle.net/10347/23781
LA eng
NO Grimaudo, M.A.; Concheiro, A.; Alvarez-Lorenzo, C. Crosslinked Hyaluronan Electrospun Nanofibers for Ferulic Acid Ocular Delivery. Pharmaceutics 2020, 12, 274
NO This research was funded by the Spanish MINECO (grant number SAF2017-83118-R), Agencia Estatal de Investigación (AEI) Spain, Xunta de Galicia (grant numbers ED431C 2016/008 and AEMAT ED431E 2018/08), and FEDER
DS Minerva
RD 28 abr 2026