RT Journal Article
T1 Polypseudorotaxanes of Pluronic® F127 with Combinations of α- and β-Cyclodextrins for Topical Formulation of Acyclovir
A1 Donato, Cristina di
A1 Iacovino, Rosa
A1 Isernia, Carla
A1 Malgieri, Gaetano
A1 Varela García, Ángela
A1 Concheiro Nine, Ángel Joaquín
A1 Álvarez Lorenzo, Carmen
K1 Pluronic® F127
K1 Cyclodextrins mixture
K1 Acyclovir
K1 Polypseudorotaxanes
K1 Solubilization
K1 Controlled release
AB Acyclovir (ACV) is one of the most used antiviral drugs for the treatment of herpes simplex virus infections and other relevant mucosal infections caused by viruses. Nevertheless, the low water solubility of ACV limits both its bioavailability and antiviral performance. The combination of block copolymer micelles and cyclodextrins (CDs) may result in polypseudorotaxanes with tunable drug solubilizing and gelling properties. However, the simultaneous addition of various CDs has barely been investigated yet. The aim of this work was to design and characterize ternary combinations of Pluronic® F127 (PF127), αCD and βCD in terms of polypseudorotaxane formation, rheological behavior, and ACV solubilization ability and controlled release. The formation of polypseudorotaxanes between PF127 and the CDs was confirmed by FT-IR spectroscopy, X-ray diffraction, and NMR spectroscopy. The effects of αCD/βCD concentration range (0–7% w/w) on copolymer (6.5% w/w) gel features were evaluated at 20 and 37 °C by rheological studies, resulting in changes of the copolymer gelling properties. PF127 with αCD/βCD improved the solubilization of ACV, maintaining the biocompatibility (hen’s egg test on the chorio-allantoic membrane). In addition, the gels were able to sustain acyclovir delivery. The formulation prepared with similar proportions of αCD and βCD provided a slower and more constant release. The results obtained suggest that the combination of Pluronic with αCD/βCD mixtures can be a valuable approach to tune the rheological features and drug release profiles from these supramolecular gels
PB MDPI
YR 2020
FD 2020
LK http://hdl.handle.net/10347/23635
UL http://hdl.handle.net/10347/23635
LA eng
NO Di Donato, C.; Iacovino, R.; Isernia, C.; Malgieri, G.; Varela-Garcia, A.; Concheiro, A.; Alvarez-Lorenzo, C. Polypseudorotaxanes of Pluronic® F127 with Combinations of α- and β-Cyclodextrins for Topical Formulation of Acyclovir. Nanomaterials 2020, 10, 613
NO This research was funded by MIUR PRIN [20157WZM8A] (Italy), MINECO [SAF2017-83118-R] (Spain), Agencia Estatal de Investigación (AEI, Spain), Xunta de Galicia [ED431C 2016/008; AEMAT ED431E 2018/08] and European Regional Development Fund (FEDER)
DS Minerva
RD 27 abr 2026