RT Journal Article
T1 Multi-Target Strategy to Uncover Unexpected Compounds in Rinse-Off and Leave-On Cosmetics
A1 Celeiro Montero, María
A1 Rubio Lareu, Laura
A1 García Jares, Carmen María
A1 Lores Aguín, Marta
K1 Cosmetics analysis
K1 Banned compounds
K1 Polycyclic aromatic hydrocarbons
K1 Pesticides
K1 Nitrosamines
K1 Alkylphenol ethoxylates
K1 Miniaturized sample preparation
K1 Gas chromatography
K1 Liquid chromatography
K1 Mass spectrometry
AB The wide range and complexity of cosmetic formulations currently available on the market poses a challenge from an analytical point of view. In addition, during cosmetics manufacture, impurities coming from raw materials or formed by reaction of different organic compounds present in the formulation may be present. Their identification is mandatory to assure product quality and consumer health. In this work, micro-matrix solid-phase dispersion (μMSPD) is proposed as a multi-target sample preparation strategy to analyze a wide number of unexpected families of compounds including polycyclic aromatic hydrocarbons (PAHs), pesticides, plasticizers, nitrosamines, alkylphenols (APs), and alkylphenol ethoxylates (APEOs). Analytical determination was performed by gas chromatography-mass spectrometry (GC-MS) for the determination of 51 target compounds in a single run, whereas liquid chromatography tandem mass spectrometry (LC-MS/MS) was employed for the analysis of six APs and APEOs. Both methodologies were successfully validated in terms of linearity, accuracy, and precision in leave-on and rinse-off cosmetics. Limits of detection (LODs) were calculated in the low ng g−1, showing their suitability to determine trace levels of impurities and banned compounds with different chemical natures, providing useful tools to cosmetic control laboratories and companies
PB MDPI
YR 2021
FD 2021
LK http://hdl.handle.net/10347/26246
UL http://hdl.handle.net/10347/26246
LA eng
NO Molecules 2021, 26(9), 2504; https://doi.org/10.3390/molecules26092504
NO This project was supported by project ED431 2020/06 (Xunta de Galicia). Authors belong to CRETUS Strategic Partnership (ED431E 2018/01) (Xunta de Galicia). All these programs are co-funded by FEDER (UE). L.R. acknowledges Xunta de Galicia for her predoctoral contract (ED481A-2018/227)
DS Minerva
RD 4 may 2026