RT Journal Article
T1 Clinical Profiling and Biomarkers for Post-Operative Atrial Fibrillation Prediction in Patients Undergoing Cardiac Surgery
A1 Iglesias Álvarez, Diego
A1 Fu, Xiaoran
A1 Martínez Cereijo, José Manuel
A1 Agra Bermejo, Rosa María
A1 Veiras Del Río, Sonia
A1 Selas Cobos, Salomé
A1 Rial Munín, María Victoria
A1 Eiras Mariño, María
A1 Martínez Salgado, Adrián
A1 Taboada Muñiz, Manuel
A1 Reija López, Laura
A1 Souaf, Souhayla
A1 García Carro, Javier
A1 Fernández González, Ángel Luis
A1 Adrio Nazar, Belén
A1 González Juanatey, José Ramón
A1 Eiras Penas, Sonia
A1 Rodríguez Mañero, Moisés
K1 Post-operative atrial fibrillation
K1 Cardiac surgery
K1 Inflammation
K1 Adiposity
K1 Biomarkers
K1 Orosomucoid
AB Post-operative atrial fibrillation (POAF) is the most common arrhythmia in the post-operative period after cardiac surgery. We aim to investigate the main clinical, local, and/or peripheral biochemical and molecular predictors for POAF in patients undergoing coronary and/or valve surgery. Between August 2020 and September 2022, consecutive patients undergoing cardiac surgery without previous history of AF were studied. Clinical variables, plasma, and biological tissues (epicardial and subcutaneous fat) were obtained before surgery. Pre-operative markers associated with inflammation, adiposity, atrial stretch, and fibrosis were analyzed on peripheral and local samples with multiplex assay and real-time PCR. Univariate and multivariate logistic regression analyses were performed in order to identify the main predictors for POAF. Patients were followed-up until hospital discharge. Out of 123 consecutive patients without prior AF, 43 (34.9%) developed POAF during hospitalization. The main predictors were cardiopulmonary bypass time (odds ratio (OR) 1.008 (95% confidence interval (CI), 1.002–1.013), p = 0.005), and plasma pre-operative orosomucoid levels (OR 1.008 (1.206–5.761). After studying differences regarding sex, orosomucoid was the best predictor for POAF in women (OR 2.639 (95% CI, 1.455–4.788), p = 0.027) but not in men. The results support the pre-operative inflammation pathway as a factor involved in the risk of POAF, mainly in women
PB MDPI
SN 2077-0383
YR 2023
FD 2023-05-19
LK http://hdl.handle.net/10347/35001
UL http://hdl.handle.net/10347/35001
LA eng
NO J. Clin. Med. 2023, 12(10), 3565
NO This study was supported by Fondo de Investigaciones Sanitarias (PI16/01282 and PI19/01330) from Plan Estatal de I+D+I and cofounded by ISCIII-Subdirección general de evaluación y fomento de la investigación del fondo europeo de desarrollo regional (FEDER), Grupos de potencial crecemento, Xunta de Galicia (IN607B 2022/04). X.F. has a predoctoral PFIS fellowship by ISCIII-Subdirección general de evaluación y fomento de la investigación del fondo europeo de desarrollo regional (FEDER)
DS Minerva
RD 24 abr 2026