RT Journal Article
T1 Patterns of Default Mode Network Deactivation in Obsessive Compulsive Disorder
A1 Gonçalves, Óscar F.
A1 Soares, José Miguel
A1 Carvalho, Sandra
A1 Leite, Jorge
A1 Ganho-Ávila, Ana
A1 Fernandes-Gonçalves, Ana
A1 Pocinho, Fernando
A1 Carracedo Álvarez, Ángel
A1 Sampaio, Adriana
AB The objective of the present study was to research the patterns of Default Mode Network (DMN) deactivation in Obsessive Compulsive Disorder (OCD) in the transition between a resting and a non-rest emotional condition. Twenty-seven participants, 15 diagnosed with OCD and 12 healthy controls (HC), underwent a functional neuroimaging paradigm in which DMN brain activation in a resting condition was contrasted with activity during a non-rest condition consisting in the presentation of emotionally pleasant and unpleasant images. Results showed that HC, when compared with OCD, had a significant deactivation in two anterior nodes of the DMN (medial frontal and superior frontal) in the non-rest pleasant stimuli condition. Additional analysis for the whole brain, contrasting the resting condition with all the non-rest conditions grouped together, showed that, compared with OCD, HC had a significantly deactivation of a widespread brain network (superior frontal, insula, middle and superior temporal, putamen, lingual, cuneus, and cerebellum). Concluding, the present study found that OCD patients had difficulties with the deactivation of DMN even when the non-rest condition includes the presentation of emotional provoking stimuli, particularly evident for images with pleasant content.
PB Nature Publishing Group
YR 2017
FD 2017
LK http://hdl.handle.net/10347/22671
UL http://hdl.handle.net/10347/22671
LA eng
NO Gonçalves, Ó., Soares, J., Carvalho, S. et al. Patterns of Default Mode Network Deactivation in Obsessive Compulsive Disorder. Sci Rep 7, 44468 (2017). https://doi.org/10.1038/srep44468
NO The first author was funded by the Brazilian National Counsel for Scientific and Technological Development (CNPq) as a Special Visiting Researcher of the Science Without Borders program (grant number: 401143/2014-7). This study was partially conducted at the Neuropsychophysiology Lab from the Psychology Research Centre (UID/PSI/01662/2013), University of Minho, and supported by the Portuguese Foundation for Science and Technology and the Portuguese Ministry of Science, Technology and Higher Education through national funds and co-financed by FEDER through COMPETE2020 under the PT2020 Partnership Agreement (POCI-01-0145- FEDER-007653)
DS Minerva
RD 27 abr 2026