RT Journal Article
T1 Tyrosinase inhibitor activity of coumarin-resveratrol hybrids
A1 Fais, Antonella
A1 Corda, Marcella
A1 Era, Benedetta
A1 Fadda, M. Benedetta
A1 Matos, Maria João Correia Pinto Carvalho de
A1 Quezada González, Elías Neftalí
A1 Santana Penín, María Lourdes
A1 Picciau, Carmen
A1 Podda, Gianni
A1 Delogu, Giovanna Lucia
K1 Tyrosinase inhibitors
K1 Resveratrol
K1 Coumarins
AB In the present work we report on the contribution of the coumarin moiety to tyrosinase inhibition. Coumarin-resveratrol hybrids 1-8 have been resynthesized to investigate the structure-activity relationships and the IC50 values of these compounds were measured. The results showed that these compounds exhibited tyrosinase inhibitory activity. Compound 3-(3’,4’,5’-trihydroxyphenyl)-6,8-dihydroxycoumarin (8)is the most potentcompound (0.27 mM), more so than umbelliferone (0.42 mM), used as reference compound. The kinetic studies revealed that compound 8 caused non-competitive tyrosinase inhibition
PB MDPI
YR 2009
FD 2009
LK http://hdl.handle.net/10347/23392
UL http://hdl.handle.net/10347/23392
LA eng
NO Fais, A.; Corda, M.; Era, B.; Fadda, M.B.; Matos, M.J.; Quezada q, E.; Santana, L.; Picciau, C.; Podda, G.; Delogu, G. Tyrosinase Inhibitor Activity of Coumarin-Resveratrol Hybrids. Molecules 2009, 14, 2514-2520.
NO We thank Progetto di Ricerca Scientifica 2007-Università di Cagliari and Fondazione del Banco diSardegna, Xunta de Galicia (PGIDIT05PXIB20304PR) and Ministerio de Sanidad y Consumo (FISPI061537 and PI061457) for financial support
DS Minerva
RD 27 abr 2026