RT Journal Article
T1 Synthesis and vasorelaxant and platelet antiaggregatory activities of a new series of 6-Halo-3-phenylcoumarins
A1 Quezada González, Elías Neftalí
A1 Delogu, Giovanna Lucia
A1 Picciau, Carmen
A1 Santana Penín, María Lourdes
A1 Podda, Gianni
A1 Borges, Fernanda
A1 García Morales, Verónica
A1 Viña Castelao, María Dolores
A1 Orallo Cambeiro, Francisco
K1 Resveratrol
K1 Coumarin
K1 Vasorelaxant
K1 Platelet antiaggregatory activity
AB A series of 6-halo-3-hydroxyphenylcoumarins (resveratrol-coumarins hybrid derivatives) was synthesized in good yields by a Perkin reaction followed by hydrolysis. The new compounds were evaluated for their vasorelaxant activity in intact rat aorta rings pre-contracted with phenylephrine (PE), as well as for their inhibitory effects on platelet aggregation induced by thrombin in washed human platelets. These compounds concentration-dependently relaxed vascular smooth muscle and some of them showed a platelet antiaggregatory activity that was up to thirty times higher than that shown by trans-resveratrol and some other previously synthesized derivatives
PB MDPI
YR 2010
FD 2010
LK http://hdl.handle.net/10347/23393
UL http://hdl.handle.net/10347/23393
LA eng
NO Quezada, E.; Delogu, G.; Picciau, C.; Santana, L.; Podda, G.; Borges, F.; García-Morales, V.; Viña, D.; Orallo, F. Synthesis and Vasorelaxant and Platelet Antiaggregatory Activities of a New Series of 6-Halo-3-phenylcoumarins. Molecules 2010, 15, 270-279
NO We thank Progetto di Ricerca Scientifica 2007-Università di Cagliari and Fondazione del Banco diSardegna, Spanish Ministerio de Sanidad y Consumo (FISS PI061537, PI061457), Xunta de Galicia(Spain; INCITE08PXIB203022PR) and Spanish Ministerio de Ciencia e Innovación (FISSPS09/00618). D. Vina acknowledges sponsorships for a tenure-track research position at theUniversity of Santiago de Compostela from the Isidro Parga Pondal Programme of the “DirecciónXeral de Investigación e Desenvolvemento, Xunta de Galicia”. E. Quezada thanks for a postdoctoralgrant from FCT (Portugal). Verónica García-Morales thanks for a predoctoral grant (FPU, AP2008-02609, Spanish Ministerio de Ciencia e Innovación). C. Picciau thanks for a predoctoral grant Master& Back-Regione Sardegna
DS Minerva
RD 27 abr 2026