RT Journal Article T1 Aqueous extracts characteristics obtained by ultrasound-assisted extraction from Ascophyllum nodosum seaweeds: effect of operation conditions A1 Gisbert Verdú, Mauro A1 Barcala García, Manuel A1 Rosell, Cristina M. A1 Sineiro Torres, Jorge K1 Antioxidant K1 Box-Behnken design K1 Carbohydrates K1 Extraction K1 Phaeophyceae K1 Polyphenols K1 Sonication K1 Uronic acids AB Aqueous extracts from Ascophyllum nodosum brown edible seaweeds were obtained after continuous ultrasound-assisted extraction. The effect of sonication time (from 2 to 6 min), sonication amplitude (from 80 to 100%) and solvent-solid ratio (from 20 to 40 g water g−1 dried seaweed) on the extracts features was studied employing a Box-Behnken experimental design. Extracts were characterised by polyphenols, carbohydrate and uronic acid content. Response surface method (by means of a quadratic model) was successfully employed to relate chemical composition of extracts and operation conditions. Optimal experimental conditions were established to obtain maximal polyphenols content and several polyphenols-carbohydrates ratios together with the conditions that minimise energy consumption per extracted polyphenols amount relationship. Antioxidant capacities of extracts were measured employing different methods (DPPH, FRAP and ABTS). Positive linear correlations between antioxidant activity and total polyphenols content were established PB Springer SN 0921-8971 YR 2021 FD 2021 LK http://hdl.handle.net/10347/28990 UL http://hdl.handle.net/10347/28990 LA eng NO Journal of Applied Phycology 33, 3297–3308 (2021). https://doi.org/10.1007/s10811-021-02546-5 NO Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. This work was supported by the Ministry of Science and Innovation of Spain and European Regional Development Fund (ERDF) of European Union by the research project (RTI2018-095919-B-C2) and Xunta de Galicia, Spain (Consolidation Project ED431B 2019/01) DS Minerva RD 24 abr 2026