RT Dissertation/Thesis
T1 Nanoengineered delivery of RNA: impact on brain diseases and COVID-19 vaccination
A1 López Borrajo, Mireya
K1 nanotechnology
K1 genetic medicine
K1 RNA
K1 central nervous system diseases
K1 vaccines
AB Genetic therapies show great potential for treating various diseases through modulation of the expression of specific genes. Their effective delivery is crucial, particularly for challenging conditions like CNS diseases and SARS-CoV-2 vaccines. Here, we used nanotechnology as a fundamental tool for RNA delivery. First, we engineered an ionizable nanoemulsion designed for brain diffusion and delivery of RNA. Second, we explored nanocarriers loaded with siRNA for brain delivery, exploring their performance following alternative administration routes. Finally, we encapsulated mRNAs derived from SARS-CoV-2 within nanoemulsions and polymeric nanocapsules, achieving significant cellular immune responses.
YR 2023
FD 2023
LK http://hdl.handle.net/10347/32336
UL http://hdl.handle.net/10347/32336
LA eng
DS Minerva
RD 23 abr 2026