RT Journal Article
T1 From the printer to the lungs: Inkjet-printed aerogel particles for pulmonary delivery
A1 García González, Carlos A.
A1 López Iglesias, Clara
A1 Casielles, Alba M.
A1 Altay, Ayca
A1 Bettini, Ruggero
A1 Álvarez Lorenzo, Carmen
K1 Aerogel
K1 Supercritical drying
K1 Salbutamol sulphate
K1 Inkjet printing
AB Inkjet printing is as an emerging technique in the biomedical field offering cost-effectivesolutions for flexible production and the engineering of personalized medicine solutions.Thermal inkjet printing technology in the “drop-on-demand” mode allows the design of fullyautomated deposition patterns with high spatial resolution for applications ranging frommicroparticles in drug formulations to cell deposition in regenerative medicine. In particular,novel formulations in the form of porous particles are sought for the treatment of respiratorydisorders and the systemic administration of bioactive compounds using the pulmonary route.Aerogel particles, i.e. highly porous and light-weight nanoporous powders, are particularlypromising as carriers for the pulmonary route. In this work, the preparation of aerogelmicrospheres by thermal inkjet printing followed by supercritical drying is presented for thefirst time to overcome the current processing limitations. Alginate aerogel particles were loadedwith salbutamol sulphate, a bronchodilator used for the treatment of asthma attacks and chronicobstructive pulmonary disease, as a model drug for sustained pulmonary delivery. Theoptimized processing method allowed the preparation of reproducible nanostructured microparticles with modified salbutamol sulphate release profile and aerodynamic performance of relevance for oral inhalation purposes
PB Elsevier
SN 1385-8947
YR 2018
FD 2018
LK http://hdl.handle.net/10347/32408
UL http://hdl.handle.net/10347/32408
LA eng
NO C. López-Iglesias, A.M. Casielles, A. Altay, R. Bettini, C. Alvarez-Lorenzo, C.A. García-González, From the printer to the lungs: Inkjet-printed aerogel particles for pulmonary delivery, Chemical Engineering Journal (2018), doi: https://doi.org/10.1016/j.cej.2018.09.159
NO This work was supported by Xunta de Galicia [grant numbers ED431F 2016/010, ED431C 2016/008] ; C.A. García-González acknowledges to MINECO for a Ramón y Cajal Fellowship [RYC2014-15239]. The authors would like to thank O’Toner Consumibles S.A. and the Technical Services Department of the USC for their valuable technical support with the selection and modifications of the inkjet cartridges and printer, respectively. Authors are also grateful to Dr. E. Solla (CACTI, Universidade de Vigo) for the technical support with the FIBSEM images.
DS Minerva
RD 24 abr 2026