RT Journal Article
T1 Ionic and Polyampholyte N-Isopropylacrylamide-Based Hydrogels Prepared in the Presence of Imprinting Ligands: Stimuli-Responsiveness and Adsorption/Release Properties
A1 Lago Crespo, Miguel Ángel
A1 Grinberg, Valerij Ya
A1 Burova, Tatiana V.
A1 Concheiro Nine, Ángel Joaquín
A1 Álvarez Lorenzo, Carmen
K1 Stimulus-responsive network
K1 Imprinted hydrogel
K1 Ionic and polyampholite hydrogels
K1 Propranolol
K1 Ibuprofen
K1 Controlled release
AB The conformation of the imprinted pockets in stimulus-responsive networks can be notably altered when the stimulus causes a volume phase transition. Such a tunable affinity for the template molecule finds interesting applications in the biomedical and drug delivery fields. Nevertheless, the effect that the binding of the template causes on the stimuli-responsiveness of the network has barely been evaluated. In this work, the effect of two ionic drugs used as templates, namely propranolol hydrochloride and ibuprofen sodium, on the responsiveness of N-isopropylacrylamide-based hydrogels copolymerized with acrylic acid (AAc) and N-(3-aminopropyl) methacrylamide (APMA) and on their ability to rebind and to control the release of the template was evaluated. The degree of swelling and, in some cases, energetics (HS-DSC) of the transitions were monitored as a function of temperature, pH, and concentration of drug. Marked decrease in the transition temperature of the hydrogels, accompanied by notable changes in the transition width, was observed in physiological NaCl solutions and after the binding of the drug molecules, which reveals relevant changes in the domain structure of the hydrogels as the charged groups are shielded. The ability of the hydrogels to rebind propranolol or ibuprofen was quantified at both 4 and 37 °C and at two different drug concentrations, in the range of those that cause major changes in the network structure. Noticeable differences between hydrogels bearing AAc or APMA and between imprinted and non-imprinted networks were also observed during the release tests in NaCl solutions of various concentrations. Overall, the results obtained evidence the remarkable effect of the template molecules on the responsiveness of intelligent imprinted hydrogels
PB MDPI
YR 2011
FD 2011
LK http://hdl.handle.net/10347/23776
UL http://hdl.handle.net/10347/23776
LA eng
NO Lago, M.A.; Grinberg, V.Y.; Burova, T.V.; Concheiro, A.; Alvarez-Lorenzo, C. Ionic and Polyampholyte N-Isopropylacrylamide-Based Hydrogels Prepared in the Presence of Imprinting Ligands: Stimuli-Responsiveness and Adsorption/Release Properties. J. Funct. Biomater. 2011, 2, 373-390
NO This work was financed by Ministerio de Ciencia y Tecnología (SAF2011-22771 and MIPFOOD IPT-060000-2010-14) and FEDER Spain, and by the RFBR (Project 04-03-32355) and DCMS RAS (Program “Creation and Study of Macromolecules and Macromolecular Structures of New Generations”)
DS Minerva
RD 1 may 2026