RT Journal Article
T1 Progression of metabolic syndrome and associated cardiometabolic risk factors from prepuberty to puberty in children: The PUBMEP study
A1 Lamas, Carmela de
A1 Kalén, Anton
A1 Ruiz Anguita, Augusto
A1 Pérez Ferreirós, Alexandra
A1 Picáns Leis, Rosaura
A1 Flores, Katherine
A1 Moreno, Luis A.
A1 Bueno, Gloria
A1 Gil, Ángel
A1 Gil Campos, Mercedes
A1 Aguilera, Concepción M.
A1 Leis Trabazo, María Rosaura
K1 adolescent
K1 cardiometabolic risk factors
K1 child
K1 metabolic syndrome
K1 obesity
K1 overweight
K1 puberty
AB Introduction: Metabolic syndrome (MetS) is a cluster of clinical and metabolic alterations related to the risk of cardiovascular diseases (CVD). Metabolic changes occurring during puberty, especially in children with overweight and obesity, can influence the risk of developing chronic diseases, especially CVD. Methods: Longitudinal study based on the follow-up until puberty of a cohort of 191 prepubertal Spanish boys and girls without congenital, chronic, or inflammatory diseases: undernutrition: or intake of any drug that could alter blood glucose, blood pressure, or lipid metabolism. The following parameters were used to determine the presence of MetS: obesity, hypertension, hyperglycemia, hypertriglyceridemia, and low HDL-c. Results: A total of 75·5% of participants stayed in the same BMI category from prepuberty to puberty, whereas 6·3% increased by at least one category. The prevalence of MetS was 9·1% (prepubertal stage) and 11·9% (pubertal stage). The risk of presenting alterations in puberty for systolic blood pressure (SBP), plasma triacylglycerols, HDL cholesterol (HDL-c), and HOMA-IR was significantly higher in those participants who had the same alterations in prepuberty. MetS prevalence in puberty was predicted by sex and levels of HOMA-IR, BMI-z, and waist circumference in the prepubertal stage, in the whole sample: in puberty, the predictors were levels of HOMA-IR, BMI-z, and diastolic blood pressure in participants with obesity. Two fast-and-frugal decision trees were built to predict the risk of MetS in puberty based on prepuberty HOMA-IR (cutoff 2·5), SBP (cutoff 106 mm of Hg), and TAG (cutoff 53 mg/dl). Discussion: Controlling obesity and cardiometabolic risk factors, especially HOMA-IR and blood pressure, in children during the prepubertal stage appears critical to preventing pubertal MetS effectively.
PB Frontiers Media
SN 1664-2392
YR 2022
FD 2022-12-19
LK https://hdl.handle.net/10347/45463
UL https://hdl.handle.net/10347/45463
LA eng
NO de Lamas, C., Kalén, A., Anguita-Ruiz, A., Pérez-Ferreirós, A., Picáns-Leis, R., Flores, K., Moreno, L. A., Bueno, G., Gil, Á., Gil-Campos, M., Aguilera, C. M., & Leis, R. (2022). Progression of metabolic syndrome and associated cardiometabolic risk factors from prepuberty to puberty in children: The PUBMEP study. Frontiers in endocrinology, 13, 1082684. https://doi.org/10.3389/fendo.2022.1082684
DS Minerva
RD 24 abr 2026