RT Journal Article
T1 Study of coumarin-resveratrol hybrids as potent antioxidant compounds
A1 Matos, Maria João Correia Pinto Carvalho de
A1 Mura, Francisco
A1 Vázquez Rodríguez, Saleta
A1 Borges, Fernanda
A1 Santana Penín, María Lourdes
A1 Uriarte Villares, Eugenio
A1 Olea Azar, Claudio
K1 Hydroxylated 3-phenylcoumarins
K1 Antioxidant assays
K1 Electrochemical study
K1 Inhibition of ROS
K1 ESR
K1 ADME properties
AB In the present work we synthesized a selected series of hydroxylated3-phenylcoumarins 5–8, with the aim of evaluating in detail their antioxidant properties.From an in depth study of the antioxidant capacity data (ORAC-FL, ESR, CV and ROSinhibition) it was concluded that these derivatives are very good antioxidants, with veryinteresting profiles in all the performed assays. The study of the effect of the number andposition of the hydroxyl groups on the antioxidant activity was the principal aim of thisstudy. In particular, 7-hydroxy-3-(3'-hydroxy)phenylcoumarin (8) proved to be the mostactive and effective antioxidant of the selected series in four of the performed assays(ORAC-FL = 11.8, capacity of scavenging hydroxyl radicals = 54%, Trolox index = 2.33and AI30 index = 0.18). However, the presence of two hydroxyl groups on this molecule didnot increase greatly the activity profile. Theoretical evaluation of ADME properties of allthe derivatives was also carried out. All the compounds can act as potential candidates forpreventing or minimizing the free radical overproduction in oxidative-stress related diseases.OPEN ACCESSMolecules 2015, 20 3291These preliminary findings encourage us to perform a future structural optimization of thisfamily of compounds
PB MDPI
YR 2015
FD 2015
LK http://hdl.handle.net/10347/22427
UL http://hdl.handle.net/10347/22427
LA eng
NO Matos, M.J., Mura, F., Vázquez Rodríguez, S., Borges, F., Santana Penín, L., Uriarte Villares, E. et al. (2015). Study of coumarin-resveratrol hybrids as potent antioxidant compounds. MDPI, vol. 20(2), 3290-3308
NO This project was partially supported by the FONDECYT (projects 1110029 and 1090078), PhDfellowship CONICYT, fellowship for operational expenses (N°21120376), Spanish researchers personalfounds, University of Santiago de Compostela and Fundação para a Ciência e Tecnologia (FCT) for thePest/C-QUI/UI0081/2013. MJ Matos was supported by the fellowship from Fundação para a Ciência eTecnologia (FCT), POPH (Programa Operacional Potencial Humano) and QREN (Quadro de ReferênciaEstratégica Nacional) (SFRH/BPD/95345/2013). S Vazquez-Rodriguez was supported by the Universidadede Porto postdoctoral grant NORTE-07-0124-FEDER-000065
DS Minerva
RD 30 abr 2026