RT Journal Article
T1 Afferent Connectivity of the Zebrafish Habenulae
A1 Turner, Katherine J.
A1 Hawkins, Thomas A.
A1 Yáñez, Julián
A1 Anadón Álvarez, Ramón
A1 Wilson, Stephen W.
A1 Folgueira Otero, Mónica
K1 Habenula
K1 Connections
K1 Afferents
K1 Entopeduncular nucleus
K1 Posterior tuberculum
K1 Basal ganglia
K1 Zebrafish
AB The habenulae are bilateral nuclei located in the dorsal diencephalon that are conserved across vertebrates. Here we describe the main afferents to the habenulae in larval and adult zebrafish. We observe afferents from the subpallium, nucleus rostrolateralis, posterior tuberculum, posterior hypothalamic lobe, median raphe; we also see asymmetric afferents from olfactory bulb to the right habenula, and from the parapineal to the left habenula. In addition, we find afferents from a ventrolateral telencephalic nucleus that neurochemical and hodological data identify as the ventral entopeduncular nucleus (vENT), confirming and extending observations of Amo et al. (2014). Fate map and marker studies suggest that vENT originates from the diencephalic prethalamic eminence and extends into the lateral telencephalon from 48 to 120 hour post-fertilization (hpf). No afferents to the habenula were observed from the dorsal entopeduncular nucleus (dENT). Consequently, we confirm that the vENT (and not the dENT) should be considered as the entopeduncular nucleus “proper” in zebrafish. Furthermore, comparison with data in other vertebrates suggests that the vENT is a conserved basal ganglia nucleus, being homologous to the entopeduncular nucleus of mammals (internal segment of the globus pallidus of primates) by both embryonic origin and projections, as previously suggested by Amo et al. (2014)
PB Frontiers Media
YR 2016
FD 2016-04-26
LK http://hdl.handle.net/10347/16018
UL http://hdl.handle.net/10347/16018
LA eng
NO Turner KJ, Hawkins TA, Yáñez J, Anadón R, Wilson SW and Folgueira M (2016) Afferent Connectivity of the Zebrafish Habenulae. Front. Neural Circuits 10:30. doi: 10.3389/fncir.2016.00030
NO This study was supported by Wellcome Trust (104682/Z/14/Z and 089227/Z09/Z) and EU FP-7 (ZF-HEALTH) Grants to SW (Orcid ID 0000–0002–8557–5940; loop: s.wilson@ucl.ac.uk); BBSRC funding (BB/H012516/1) to SWW and TAH (Orcid ID 0000-0003-2921-0004)
DS Minerva
RD 28 abr 2026