RT Journal Article
T1 Temperature-Induced Changes in Reperfused Stroke: Inflammatory and Thrombolytic Biomarkers
A1 Ávila Gómez, Paulo
A1 Hervella Lorenzo, Pablo
A1 Silva Candal, Andrés da
A1 Pérez Mato, María
A1 Rodríguez Yáñez, Manuel
A1 López Dequidt, Iria Alejandra
A1 Pumar Cebreiro, José Manuel
A1 Castillo Sánchez, José Antonio
A1 Sobrino Moreiras, Tomás
A1 Iglesias Rey, Ramón
A1 Campos Pérez, Francisco
K1 Biomarkers
K1 Ischemic stroke
K1 Recanalization therapy
K1 Reperfusion
K1 Temperature
AB Although hyperthermia is associated with poor outcomes in ischaemic stroke (IS), some studies indicate that high body temperature may benefit reperfusion therapies. We assessed the association of temperature with effective reperfusion (defined as a reduction of ≥8 points in the National Institute of Health Stroke Scale (NIHSS) within the first 24 h) and poor outcome (modified Rankin Scale (mRS) > 2) in 875 retrospectively-included IS patients. We also studied the influence of temperature on thrombolytic (cellular fibronectin (cFn); matrix metalloproteinase 9 (MMP-9)) and inflammatory biomarkers (tumour necrosis factor-alpha (TNF-α), interleukin 6 (IL-6)) and their relationship with effective reperfusion. Our results showed that a higher temperature at 24 but not 6 h after stroke was associated with failed reperfusion (OR: 0.373, p = 0.001), poor outcome (OR: 2.190, p = 0.005) and higher IL-6 levels (OR: 0.958, p < 0.0001). Temperature at 6 h was associated with higher MMP-9 levels (R = 0.697; p < 0.0001) and effective reperfusion, although this last association disappeared after adjusting for confounding factors (OR: 1.178, p = 0.166). Our results suggest that body temperature > 37.5 °C at 24 h, but not at 6 h after stroke, is correlated with reperfusion failure, poor clinical outcome, and infarct size. Mild hyperthermia (36.5–37.5 °C) in the first 6 h window might benefit drug reperfusion therapies by promoting clot lysis
PB MDPI
YR 2020
FD 2020
LK http://hdl.handle.net/10347/23856
UL http://hdl.handle.net/10347/23856
LA eng
NO Ávila-Gómez, P.; Hervella, P.; Da Silva-Candal, A.; Pérez-Mato, M.; Rodríguez-Yáñez, M.; López-Dequidt, I.; Pumar, J.M.; Castillo, J.; Sobrino, T.; Iglesias-Rey, R.; Campos, F. Temperature-Induced Changes in Reperfused Stroke: Inflammatory and Thrombolytic Biomarkers. J. Clin. Med. 2020, 9, 2108
NO This study was partially supported by grants from the Spanish Ministry of Science and Innovation (SAF2017-84267-R), Xunta de Galicia (Consellería Educación: IN607A2018/3), Instituto de Salud Carlos III (ISCIII) (PI17/00540 and PI17/01103), Spanish Research Network on Cerebrovascular Diseases RETICS-INVICTUS PLUS (RD16/0019), and by the European Union FEDER program. Furthermore, Tomás. Sobrino (CPII17/00027) and Francisco Campos (CPII19/00020) are recipients of research contracts from the Miguel Servet Program of Instituto de Salud Carlos III. María Pérez-Mato is a Sara Borrell Researcher (CD19/00033)
DS Minerva
RD 30 abr 2026