RT Journal Article
T1 Efficient synthesis of β-aminonitriles from arynes and imines in acetonitrile
A1 Gómez Pérez, Inmaculada Jénnifer
A1 Mariño, Cristina
A1 Pérez Meirás, María Dolores
A1 Guitián Rivera, Enrique
A1 Peña Gil, Diego
K1 Beta-aminonitriles
K1 Arynes
K1 Imines
K1 Synthesis
K1 Multicomponent reactions
AB Multicomponent reactions are powerful strategies for synthesizing complex molecules in an efficient manner. In this work, we investigate a novel multicomponent reaction involving arynes, imines, and nitriles, leading to chiral β-aminonitriles. Notably, two new bonds (C–C and C–N) are formed in one step without the use of metal catalysts, showing the great potential of this transformation. We demonstrate that this synthetic methodology is compatible with different arynes and imines, and propose a reasonable reaction mechanism initiated by the nucleophilic addition of the imine to the aryne.
PB Royal Society of Chemistry
SN 2046-2069
YR 2024
FD 2024-10-23
LK https://hdl.handle.net/10347/38102
UL https://hdl.handle.net/10347/38102
LA eng
NO Xunta de Galicia (Centro de Investigación do Sistema Universitario de Galicia, 2023-2027, ED431G 2023/03 and Oportunius Program)
NO European Union (European Regional Development Fund – ERDF)
DS Minerva
RD 24 abr 2026