RT Journal Article
T1 Efficacy of adjunctive measures in the non-surgical treatment of peri-implantitis: A systematic review
A1 Liñares, Antonio
A1 Sanz Sánchez, Ignacio
A1 Dopico García, José Luis
A1 Molina Villar, Ana Rosario
A1 Blanco Carrión, Juan
A1 Montero Solís, Eduardo
K1 Adjuncts
K1 Antimicrobials
K1 Non-surgical treatmen
K1 Peri-implantitis
K1 Probiotics
AB AimThe aim of this systematic review was to evaluate the efficacy of patient-performed or administered adjunctive measures to non-surgical peri-implantitis therapy in terms of probing depth (PD) and/or bleeding on probing (BoP) reductions.Materials and MethodsRandomized and controlled clinical trials with at least 6 months of follow-up were searched in three databases. Secondary outcomes included implant loss, disease resolution, recurrence of peri-implantitis, need of re-treatment, changes in marginal bone levels, patient-reported outcomes and adverse effects.ResultsOf 567 titles, 10 publications, reporting 9 investigations, were included. Three types of adjunctive measures were found (local/systemic antimicrobials and probiotics). Four studies evaluated the effects of local antimicrobials (i.e., minocycline microspheres, chlorhexidine chips or a metronidazole + amoxicillin gel), three studies evaluated systemic antimicrobials (either amoxicillin + metronidazole or metronidazole alone) and two studies evaluated probiotics (Lactobacillus reuteri strains). The addition of local antimicrobials led to modest improvements in PD reduction. Systemic antimicrobials showed significantly greater reductions in PD and BoP, especially at initially deep sites (PD > 6 mm). Due to the large heterogeneity among included studies, no meta-analyses were performed.ConclusionsDifferent adjunctive measures in the non-surgical treatment of peri-implantitis have different impact in terms of PD and BoP reductions. Improved PD reductions result after the use of systemic antimicrobials, and to a lesser extent, after the use of local antimicrobials
PB Wiley
SN 0303-6979
YR 2023
FD 2023-05-04
LK https://hdl.handle.net/10347/41329
UL https://hdl.handle.net/10347/41329
LA eng
NO Liñares, A., Sanz-Sánchez, I., Dopico,J., Molina, A., Blanco, J., & Montero, E. (2023). Efficacy ofadjunctive measures in the non-surgical treatment of peri-implantitis: A systematic review. Journal of Clinical Periodontology, 50(Suppl. 26), 224–243. https://doi.org/10.1111/jcpe.13821
DS Minerva
RD 28 abr 2026