RT Journal Article T1 Trends in smoking-attributable mortality in Spain: 1990–2018 A1 Rey Brandariz, Julia A1 Pérez Ríos, Mónica A1 Santiago Pérez, María Isolina A1 Galán Labaca, Iñaki A1 Schiaffino, Anna A1 Varela Lema, María Leonor A1 Montes Martínez, Agustín A1 López Vizcaíno, María Esther A1 Giraldo Osorio, Alexandra A1 Candal Pedreira, Cristina A1 Ruano Raviña, Alberto K1 Tobacco AB Background: This study sought to analyse the trend in smoking-attributable mortality (SAM) in Spain among the population aged 35 years across the period 1990–2018. Methods: SAM was estimated by applying a prevalenceindependent method, which uses lung cancer (LC) mortality as a proxy of tobacco consumption. We sourced observed mortality from the National Institute of Statistics (Spain), LC mortality rates in smokers and never smokers from the Cancer Prevention Study I–II, and relative risks from 5 US cohorts. Estimates of annual SAM by cause of death, sex and age are shown, along with crude and annual standardised SAM rates. The trend in standardised all-cause and LC rates was analysed using a joinpoint regression model. Results: Tobacco caused 1 717 150 deaths in Spain in the period 1990–2018. Among men, cancers replaced cardiovascular diseases–diabetesmellitus (CVD–DM) as the leading group of tobacco-related cause of death in 1994. Among women, CVD–DM remained the leading cause of death throughout the period. Trend analysis of standardised SAM rates due to all causes and LC showed a decrease in men and an increase in women. Conclusions: The tobacco epidemic in Spain across the period 1990–2018 has had an important impact on mortality and has evolved differently in bothgenders. SAM is expected to increase dramatically in women in the coming years. SAM data highlight the importance of including a gender perspective in SAM analyses, in designing more effective and comprehensive public health interventions and in developing gender-specific tobacco control policies to curb tobacco consumption PB Oxford University Press SN 1101-1262 YR 2022 FD 2022 LK http://hdl.handle.net/10347/29728 UL http://hdl.handle.net/10347/29728 LA eng NO Julia Rey-Brandariz, Mónica Pérez-Ríos, María Isolina Santiago-Pérez, Iñaki Galán, Anna Schiaffino, Leonor Varela-Lema, Agustín Montes, María Esther López-Vizcaíno, Alexandra Giraldo-Osorio, Cristina Candal-Pedreira, Alberto Ruano-Ravina, Trends in smoking-attributable mortality in Spain: 1990–2018, European Journal of Public Health, Volume 32, Issue 6, December 2022, Pages 919–925, https://doi.org/10.1093/eurpub/ckac165 DS Minerva RD 29 abr 2026