RT Journal Article
T1 Relationship between anemia and oral lichen planus: New therapeutic perspectives based on anemia management: A systematic review and meta-analysis
A1 Egido Moreno, Sonia
A1 Valls Roca-Umbert, Joan
A1 Schemel Suárez, Mayra
A1 Vidal Bel, August
A1 Blanco Carrión, Andrés
A1 López López, José
K1 Oral lichen planus
K1 Anemia
K1 Iron deficiency
K1 Vitamin B12 deficiency
K1 Folic acid deficiency
AB Anemia is a multifactorial condition influenced by nutritional deficiencies, chronic diseases, and inflammatory processes. These factors not only contribute to anemia but may also exacerbate oral conditions such as Oral Lichen Planus (OLP) by impairing epithelial integrity and immune function. By synthesizing published studies, this review seeks to clarify whether anemia is associated with OLP and to highlight biological mechanisms common to both conditions that could be relevant for future therapeutic development. Methods: A comprehensive literature search was conducted across the selected electronic databases: Medline/Pubmed, Scopus, and Cochrane. Methodological quality and potential bias of the included studies were evaluated using the Newcastle–Ottawa Scale (NOS), while the overall certainty of the evidence was appraised according to the Grades of Recommendation, Assessment, Development and Evaluation (GRADE) framework. Forest plots were generated using the Cochrane RevMan software to evaluate and visually summarize the results of the included studies. Results: Application of the search strategy resulted in the identification of 549 articles; after applying exclusion and inclusion criteria, 11 papers were selected. The prevalence of anemia, iron deficiency, and folic acid deficiency was significantly increased in the study population (p < 0.05); whereas hemoglobin deficiency was observed exclusively in women with statistical significance (p < 0.00001), driven by a single large study. Conclusions: Patients with OLP show a higher prevalence of anemia and deficiencies in key hematologic micronutrients such as vitamin B12, folic acid, and iron. Routine laboratory evaluation is recommended to detect and manage these systemic alterations. In addition to corticosteroid therapy, micronutrient supplementation may serve as a useful complementary treatment approach.
PB Multidisciplinary Digital Publishing Institute MDPI
SN 2077-0383
YR 2026
FD 2026-01-11
LK https://hdl.handle.net/10347/47270
UL https://hdl.handle.net/10347/47270
LA eng
NO Egido-Moreno, S., Valls-Roca-Umbert, J., Schemel-Suárez, M., Vidal-Bel, A., Blanco-Carrión, A., & López-López, J. (2026). Relationship Between Anemia and Oral Lichen Planus: New Therapeutic Perspectives Based on Anemia Management—A Systematic Review and Meta-Analysis. Journal of Clinical Medicine, 15(2), 581. https://doi.org/10.3390/jcm15020581
NO This research received no external funding.
DS Minerva
RD 23 may 2026