RT Journal Article
T1 Integrating Genomic and Morphological Approaches in Fish Pathology Research: The Case of Turbot (Scophthalmus maximus) Enteromyxosis
A1 Ronza, Paolo
A1 Robledo Sánchez, Diego
A1 Bermúdez Pose, Roberto
A1 Losada García, Ana Paula
A1 Gómez Pardo, María Belén
A1 Martínez Portela, Paulino
A1 Quiroga Berdeal, María Isabel
K1 Scophthalmus maximus
K1 Pathogenesis
K1 Histopathology
K1 Transcriptomics
AB Enteromyxosis, caused by Enteromyxum scophthalmi, is one of the most devastatingdiseases stemming from myxozoan parasites in turbot (Scophthalmus maximus L.),being a limiting factor for its production. The disease develops as a cachectic syndrome,associated to catarrhal enteritis and leukocytic depletion, with morbidity and mortalityrates usually reaching 100%. To date, no effective treatment exists and there aredifferent unknown issues concerning its pathogenesis. The gross and microscopiclesions associated to enteromyxosis have been thoroughly described, and severalmorphopathological studies have been carried out to elucidate the mechanisms of thishost-parasite interaction. More recently, efforts have been focused on a multidisciplinaryapproach, combining histopathology and transcriptome analysis, which has providedsignificant advances in the understanding of the pathogenesis of this parasitosis. RNASeq technology was applied at early and advanced stages of the disease on fisheshistologically evaluated and classified based on their lesional degree. In the same way,the transcriptomic data were analyzed in relation to the morphopathological picture andthe course of the disease. In this paper, a comprehensive review of turbot enteromyxosisis presented, starting from the disease description up to the most novel informationextracted by an integrated approach on the infection mechanisms and host response.Further, we discuss ongoing strategies toward a full understanding of host-pathogeninteraction and the identification of suitable biomarkers for early diagnosis and diseasemanagement strategies.
PB Frontiers Media
YR 2019
FD 2019
LK http://hdl.handle.net/10347/20988
UL http://hdl.handle.net/10347/20988
LA eng
NO Ronza P, Robledo D, Bermúdez R, Losada AP, Pardo BG, Martínez P and Quiroga MI (2019) Integrating Genomic and Morphological Approaches in Fish Pathology Research: The Case of Turbot (Scophthalmus maximus) Enteromyxosis. Front. Genet. 10:26. doi: 10.3389/fgene.2019.00026
NO This work was supported by the European Regional Development Fund (ERDF) together with the Spanish Ministry of Economy, Industry and Competitiveness through the projects AGL2015–67039–C3–1–R and AGL2015–67039–C3–3–R. DR was supported by a Newton International Fellowship from The Royal Society (NF160037)
DS Minerva
RD 28 abr 2026