RT Journal Article
T1 Concurrent and orthogonal gold(I) and ruthenium(II) catalysis inside living cells
A1 Vidal Vides, Cristian
A1 Tomás Gamasa, María
A1 Destito, Paolo
A1 López García, Fernando
A1 Mascareñas Cid, José Luis
K1 Chemical biology
K1 Homogeneous catalysis
K1 Organometallic chemistry
AB The viability of building artificial metabolic pathways within a cell will depend on our ability todesign biocompatible and orthogonal catalysts capable of achieving non-natural transformations.In this context, transition metal complexes offer unique possibilities to developcatalytic reactions that do not occur in nature. However, translating the potential of metalcatalysts to living cells poses numerous challenges associated to their biocompatibility, andtheir stability and reactivity in crowded aqueous environments. Here we report a goldmediatedC–C bond formation that occurs in complex aqueous habitats, and demonstratethat the reaction can be translated to living mammalian cells. Key to the success of theprocess is the use of designed, water-activatable gold chloride complexes. Moreover, wedemonstrate the viability of achieving the gold-promoted process in parallel with aruthenium-mediated reaction, inside living cells, and in a bioorthogonal and mutuallyorthogonal manner
PB Springer Nature
YR 2018
FD 2018
LK http://hdl.handle.net/10347/17632
UL http://hdl.handle.net/10347/17632
LA eng
NO Vidal, C., Tomás-Gamasa, M., Destito, P., López, F., & Mascareñas, J. (2018). Concurrent and orthogonal gold(I) and ruthenium(II) catalysis inside living cells. Nature Communications, 9(1). doi: 10.1038/s41467-018-04314-5
NO This work has received financial support from Spanish grants (SAF2013-41943-R, SAF2016-76689-R, Orfeo-cinqa network CTQ2016-81797-REDC), the Xunta de Galicia (2015-CP082, ED431C 2017/19, and Centro Singular de Investigación de Galicia accreditation 2016-2019, ED431G/09), the European Union (European Regional Development Fund-ERDF), and the European Research Council (Advanced Grant No. 340055). M.T.G. thanks the Ministerio de Economía y Competitividad for the Juan de la Cierva-Incorporación fellowship (IJCI-2015-23210)
DS Minerva
RD 27 abr 2026