RT Journal Article
T1 Different Fish-Eating Habits and Cytokine Production in Chronic Urticaria with and without Sensitization against the Fish-Parasite Anisakis simplex
A1 Daschner, Álvaro
A1 Fernández Fígares, Virginia
A1 Valls, Ana
A1 Frutos, Consolación de
A1 Rodero, Marta
A1 Martínez Ubeira, Florencio César
A1 Cuéllar, Carmen
K1 Anisakis simplex
K1 Chronic urticaria
K1 Cytokines
K1 Diet
K1 Phenotype
AB Background:Anisakis simplexsensitization has been associated with acute, but also with chronic urticaria.The objective of this study is to characterize chronic urticaria with (CU+) and without sensitization (CU-) againstthe ubiquitous fish parasiteA. simplexin a transversal and longitudinal evaluation.Methods:16 CU+ and 22 CU- patients were included and assessed for Urticaria activity score (UAS), fish-eating habits by standardized questionnaire and cytokine production (assessed by flow cytometric bead-basedarray) of peripheral blood mononuclear cells after stimulation withA. simplexextract or Concanavalin A (ConA). Patients were randomly put on a fish-free diet for three months and UAS, as well as cytokine productionwere again assessed. A difference of"1 in UAS was defined as improvement.Results:There was no difference in UAS in both groups.Anisakisinduced IL-2, IL-4 and IFN-γproduction washigher in CU+. Con A induced IL-6 and IL-10 production was higher in CU+. CU+ was associated with highertotal fish intake, whereas CU- was associated with oily fish intake. The correlation of UAS was positive with oilyfish, but negative with total fish intake.There was a better UAS-based prognosis in CU+ without diet. Improvement was associated with higher ConA induced IL-10!IFN-γas well as IL-10!IL-6 ratios. Further, previous higher oily fish intake was associated withimprovement.Conclusions:Our data confirm the different clinical and immunological phenotype of CU+. Our results show acomplex relationship between fish-eating habits, cytokine production and prognosis, which could have impor-tant consequences in dietary advice in patients with CU. When encounteringA. simplexsensitization, patientsshould not be automatically put on a diet without fish in order to reduce contact withA. simplexproducts
PB Elsevier
SN 1323-8930
YR 2013
FD 2013
LK http://hdl.handle.net/10347/21818
UL http://hdl.handle.net/10347/21818
LA eng
NO Daschner, A., Fernández Figares, V., Valls, A., de Frutos, C., Roder, M., Ubeira, F.M., et al.(2013). Different fish-eating habits and cytokine production in chronic urticaria with and without sensitization against the fish-parasite anisakis simplex. Allergology international, vol. 62, 191-201
NO The study was funded by grants from Fundación Sociedad Española de Alergología e Inmunología Clínica (SEAIC) 2009 and Fundación Mutua Madrileña 2009, Spain
DS Minerva
RD 24 abr 2026