RT Journal Article
T1 Applicability of mixed-mode chromatography for the simultaneous analysis of C1-C18 perfluoroalkylated substances
A1 Montes Goyanes, Rosa
A1 Rodil Rodríguez, María del Rosario
A1 Placer Vidal, Lorena
A1 Wilms, Jonas M.
A1 Cela Torrijos, Rafael
A1 Quintana Álvarez, José Benito
K1 Perfluoroalkyl carboxylic acids (PFCAs)
K1 Perfluoroalkyl sulfonic acids (PFSAs)
K1 Persistent and mobile organic contaminants (PMOCs)
K1 Solid-phase extraction
K1 Water samples
AB A new analytical method for the determination of 22 perfluoroalkylated (carboxylic and sulfonic) acids in water samples is presented. The method's objective was to achieve the simultaneous quantification of compounds with different chain lengths (from C1 to C18). To this end, 500 mL of water were extracted with Oasis WAX solid-phase extraction cartridges and eluted with 3 mL of 5% ammonia in methanol. After evaporation to dryness, extracts were reconstituted in methanol:ultrapure water (1:1) and analyzed by mixed-mode liquid chromatography-tandem mass spectrometry (MMLC-MS/MS) using a weak anion exchange/reversed-phase column. The method provided good results, with limits of quantification lower than 1 ng/L in river water for most of compounds, except the two perfluorocarboxylic acids with the longest alkyl chain (>C14) and trifluoroacetic acid, for which a blank contamination problem was observed. The method proved good trueness and precision in both ultrapure and river water (R ≥ 81%, RSD ≤ 15%). After validation, the method was applied to the analysis of nine water samples where nine perfluoroalkylated acids were quantified. Seven of them were ultrashort- (C1-C4) and short-chain (C4-C8) perfluoroalkylated acids, pointing out the importance of developing methods capable to target such substances for further monitoring
PB Springer
SN 1618-2642
YR 2020
FD 2020
LK http://hdl.handle.net/10347/26078
UL http://hdl.handle.net/10347/26078
LA eng
NO Analytical and Bioanalytical Chemistry (2020) 412:4849–4856
NO This is a post-peer-review, pre-copyedit version of an article published in Analytical and Bioanalytical Chemistry. The final authenticated version is available online at: https://doi.org/10.1007/s00216-020-02434-w
NO This work was supported by the Water Challenges for a Changing World Joint Program Initiative (Water JPI) Pilot Call (ref. WATERJPI2013 – PROMOTE), the Spanish Ministry of Economy and Competitiveness/Spanish Agencia Estatal de Investigación (refs. JPIW2013-117 and CTM2017-84763-C3-2-R), the Galician Council of Culture, Education and Universities (ref. ED431C2017/36) and FEDER/EDRF funding
DS Minerva
RD 27 abr 2026