RT Journal Article
T1 Brain atrophy and clinical characterization of adults with mild cognitive impairment and different cerebrospinal fluid biomarker profiles according to the AT(N) research framework of Alzheimer’s disease
A1 Rivas Fernández, Miguel Ángel
A1 Lindín, Mónica
A1 Zurrón Ocio, Montserrat
A1 Díaz Fernández, Fernando
A1 Aldrey Vázquez, José Manuel
A1 Pías Peleteiro, Juan Manuel
A1 Vázquez-Vázquez, Laura
A1 Pereiro Rozas, Arturo X.
A1 Lojo Seoane, Cristina
A1 Nieto Vieites, Ana
A1 Galdo Álvarez, Santiago
K1 Alzheimer’s Disease (AD)
K1 AT(N)
K1 Amyloid
K1 Tau
K1 Structural magnetic resonance imaging (sMRI)
K1 Clinical diagnosis
AB Introduction: This study aimed to evaluate, in adults with mild cognitive impairment (MCI), the brain atrophy that may distinguish between three AT(N) biomarker-based profiles, and to determine its clinical value.Methods: Structural MRI (sMRI) was employed to evaluate the volume and cortical thickness differences in MCI patients with different AT(N) profiles, namely, A−T−(N)−: normal AD biomarkers; A+T−(N)−: AD pathologic change; and A+T+(N)+: prodromal AD. Sensitivity and specificity of these changes were also estimated.Results: An initial atrophy in medial temporal lobe (MTL) areas was found in the A+T−(N)− and A+T+(N)+ groups, spreading toward the parietal and frontal regions in A+T+(N)+ patients. These structural changes allowed distinguishing AT(N) profiles within the AD continuum; however, the profiles and their pattern of neurodegeneration were unsuccessful to determine the current clinical status.Conclusion: sMRI is useful in the determination of the specific brain structural changes of AT(N) profiles along the AD continuum, allowing differentiation between MCI adults with or without pathological AD biomarkers
PB Frontiers Media
SN 1662-5161
YR 2022
FD 2022
LK http://hdl.handle.net/10347/29974
UL http://hdl.handle.net/10347/29974
LA eng
NO Rivas-Fernández MÁ, Lindín M, Zurrón M, Díaz F, Aldrey-Vázquez JM, Pías-Peleteiro JM, Vázquez-Vázquez L, Pereiro AX, Lojo-Seoane C, Nieto-Vieites A and Galdo-Álvarez S (2022) Brain atrophy and clinical characterization of adults with mild cognitive impairment and different cerebrospinal fluid biomarker profiles according to the AT(N) research framework of Alzheimer’s disease. Front. Hum. Neurosci. 16:799347
NO This study was supported by grants from the SpanishGovernment, Ministerio de Ciencia e Innovación (PSI2017-89389-C2-R and PID2020-114521RB-C21/C22); theGalician Government, Axudas para a Consolidación eEstruturación de Unidades de Investigación Competitivasdo Sistema Universitario de Galicia: GRC (GI-1807-USC); Refs: ED431-2017/27 and ED431C-2021/04; all withERDF/FEDER funds
DS Minerva
RD 4 may 2026