RT Dissertation/Thesis
T1 Epigenetic and genetic profiling of cell-free DNA for precision oncology in colorectal and breast cancer
A1 Rodríguez Casanova, Aitor
K1 Epigenetics
K1 Genetics
K1 Liquid biopsy
K1 Biomarkers
K1 Precision oncology
AB Colorectal and breast cancer are among the most frequenttypes of cancer. The identification of novel non-invasivegenetic and epigenetic biomarkers is crucial to improve themanagement of this disease. This thesis evaluated theperformance of a novel NGS targeted panel for the noninvasivedetection of clinically relevant gene variants in cell-free DNA (cfDNA). Furthermore, this work characterized thecfDNA methylation profile of colorectal and breast cancerpatients, providing non-invasive epigenetic biomarkers andsignatures useful for the early detection of the disease andtherapy selection. Therefore, the results obtained in this studywill contribute to improve the management of colorectaland breast cancer, facilitating the advance towards precisiononcology.
YR 2024
FD 2024
LK http://hdl.handle.net/10347/34220
UL http://hdl.handle.net/10347/34220
LA eng
DS Minerva
RD 26 abr 2026