RT Journal Article
T1 Facile generation of surface diversity in gold nanoparticles
A1 Paz Castañal, Manuel María
A1 Peinador Veiga, Alberto
A1 Regueira, Tamara
A1 Vázquez Vázquez, Carlos
A1 López Quintela, Manuel Arturo
K1 Gold nanoparticles
K1 Surface modification
K1 Anhydrides
K1 Mixed-charge
K1 Charge-reversal
AB Surface chemistry is a key determinant of the physico-chemical and biological properties of gold nanoparticles (AuNPs). The introduction of chemical diversity in the surface of AuNPs is usually accomplished by place-exchange reactions using incoming ligands containing the desired terminal functional groups. As an alternative approach, we present here a simple, practical methodology to modify the surface of gold nanoparticles that allows the preparation of AuNPs stabilized with polyethyleneglycol (PEG) ligands with different surface chemistries using AuNPs stabilized with thiol-PEG-amino ligands as starting material. The surface modification reaction involves the acylation of the terminal amino groups in the ligand with an organic acid anhydride in an aqueous buffer. In addition to a full surface modification, this method also allows the synthesis of AuNPs with tailored mixed surfaces, containing two or more different functional groups, each of them at the desired extent. The ease of the experimental conditions for the reaction, purification, and for determining the level of surface modification makes this strategy an attractive alternative to current methods for the preparation of AuNPs with diverse surface chemistry
PB Elsevier
YR 2023
FD 2023
LK http://hdl.handle.net/10347/30617
UL http://hdl.handle.net/10347/30617
LA eng
NO Journal of Colloid and Interface Science 641 (2023) 719-728
NO We thank the Xunta de Galicia (Galician Competitive Research Groups GRC/ED431B/2021/004 to MMP, GRC/ED431C/2021/16 to CVV and MALQ, co-funded by FEDER) and iMATUS for financial support. This research was partly supported by HP-NANOBIO Project PID2019-111163RB-I00 and SPOTLIGHT Project PDC2021-121540-I00, granted by Spanish Ministry of Science (MCIN/AEI/10.13039/501100011033) and co-funded by NextGenerationEU/PRTR
DS Minerva
RD 24 abr 2026