RT Journal Article
T1 Oral amoxicillin/clavulanate for the prevention of bacteremia following dental extractions
A1 Diniz Freitas, Márcio
A1 Álvarez Fernández, Maximiliano
A1 Vasallo Vidal, Francisco José
A1 Limeres Posse, Jacobo
A1 Diz Dios, Pedro
A1 Fernández Feijoo, Javier
K1 Amoxicillin/clavulanate
K1 Antibiotic prophylaxis
K1 Bacteremia
K1 Dental extractions
K1 Endocarditis
AB This study aimed to evaluate the effectiveness of oral amoxicillin/clavulanate (AMX-CL) for the prevention of bacteremia following dental extractions. The study group (AMX-CLG) comprised 40 adults requiring dental extractions under general anesthesia who were administered a prophylactic regimen of 1875/125 mg of AMX-CL orally 1–2 h prior to the surgery. Venous blood samples were collected from each patient at baseline and at 30 s and 15 min after dental extractions. Samples were inoculated into BACTEC Plus culture bottles and processed in the BACTEC 9240. Conventional microbiological techniques were used for subcultures and further identification of the isolated bacteria. The results for the AMX-CLG were compared with those of a control group (CG; no prophylaxis) and an amoxicillin group (AMXG; 2 g of amoxicillin orally), consisting of randomly selected patients from among those participating in two clinical trials that we have previously published. The prevalence of bacteremia in the CG, AMXG, and AMX-CLG was 97%, 50%, and 15%, respectively, at 30 s after completing the extractions, and 67%, 10%, and 4% at 15 min, respectively, after the last extraction. The prevalence of bacteremia in the AMXG and the AMX-CLG at 30 s and at 15 min after completing the extractions was significantly lower than that in the CG (p < 0.001 and p < 0.001, respectively; Fisher’s exact test). The prevalence of bacteremia in the AMX-CLG at 30 s after completing the extractions was significantly lower than that in the AMXG (p < 0.001; Fisher’s exact test). Based in the results of this preliminary study, oral AMX-CL could be an excellent option for preventing bacteremia secondary to dental procedures in patients at risk
PB Wiley
YR 2022
FD 2022
LK http://hdl.handle.net/10347/29272
UL http://hdl.handle.net/10347/29272
LA eng
NO Diniz Freitas, M., Álvarez Fernández, M., Vasallo Vidal, F. J., Limeres Posse, J., Diz Dios, P., & Fernández Feijoo, J. (2022). Oral amoxicillin/clavulanate for the prevention of bacteremia following dental extractions. Oral Diseases, 00,  1– 5. https://doi.org/10.1111/odi.14221
DS Minerva
RD 26 abr 2026