RT Journal Article
T1 Predictive value of CDKN2A/p16INK4a expression in the malignant transformation of oral potentially malignant disorders: Systematic review and meta-analysis
A1 Lorenzo Pouso, Alejandro Ismael
A1 Caponio, Vito Carlo Alberto
A1 Vieira e Silva, Fábio França
A1 Pérez-Jardón, Alba
A1 Álvarez-Calderón-Iglesias, Óscar
A1 Gándara Vila, Pilar
A1 Pannone, Giuseppe
A1 Pérez-Sayáns García, Mario
K1 p16INK4a Gene
K1 OPMD
K1 Meta-analysis
K1 Prognosis
K1 Immunohistochemistry
AB BackgroundManagement of oral potentially malignant disorders (OPMDs) is still challenging. Despite the diagnostic ascertainment by bioptic examination, this method is poorly informative of the prognosis and subsequent malignant transformation. Prognosis is based on histological findings by grading of dysplasia. Immunohistochemical expression of p16INK4a has been investigated in different studies, with controversial results. In this scenario, we systematically revised the current evidence about p16INK4a immunohistochemical expression and the risk of malignization of OPMDs.Material and methodsAfter a proper set of keywords combination, 5 databases were accessed and screened to select eligible studies. The protocol was previously registered on PROSPERO (Protocol ID: CRD42022355931). Data were obtained directly from the primary studies as a measure to determine the relationship between CDKN2A/P16INK4a expression and the malignant transformation of OPMDs. Heterogeneity and publication bias were investigated by different tools, such as Cochran's Q test, Galbraith plot and Egger and Begg Mazumdar’s rank tests.ResultsMeta-analysis revealed a twofold increased risk to malignant development (RR = 2.01, 95% CI = 1.36–2.96 - I2 = 0%). Subgroup analysis did not highlight any relevant heterogeneity. Galbraith plot showed that no individual study could be considered as an important outlier.ConclusionPooled analysis showed that p16INK4a assessment may arise adjunct tool to dysplasia grading, leading to an optimized determination of the potential progression to cancer of OPMDs. The p16INK4a overexpression analysis by immunohistochemistry techniques has a multitude of virtues that may facilitate its incorporation in the day-to-day prognostic study of OPMDs
PB Elsevier
SN 0344-0338
YR 2023
FD 2023-06-29
LK http://hdl.handle.net/10347/31265
UL http://hdl.handle.net/10347/31265
LA eng
NO Pathology - Research and Practice 248 (2023) 154656
DS Minerva
RD 24 abr 2026