RT Journal Article
T1 Evaluation of pleural effusion sCD26 and DPP-IV as diagnostic biomarkers in lung disease
A1 Sánchez Otero, Nuria
A1 Rodríguez Berrocal, Francisco Javier
A1 Páez de la Cadena, María
A1 Botana Rial, María Isabel
A1 Cordero Santamaría, Óscar Javier
K1 Diagnostic markers
K1 Lymphocyte differentiation
K1 Hydrolases
K1 Proteomics
AB In this study, we measured ADA and DPP-IV enzymatic activity and sCD26 concentration in 150 pleuraleffusion (PE) samples and tested for correlations between these and other cellular and biochemicalmeasures. We found that DPP-IV in particular might improve the specificity (but not the sensitivity) of theADA test for diagnosis of pulmonary tuberculosis, since half of the false ADA positive results innon-tuberculous PE were also DPP-IV positive. A percentage of patients with malignant PE were sCD26 orDPP-IV positive; however, some patients with benign PE also tested positive. As a pattern associated withDPP-IV (but not the CD26 protein) was observed in PE, we searched for a finding that might increase thevalue of these biomarkers for diagnosis of malignancy. The observed pattern was related to the presence ofleukocytes, as indicated by correlations with the cell count, and to a band of 180 kDa, detected byimmunoblotting
PB Nature Publishing Group
YR 2015
FD 2015
LK http://hdl.handle.net/10347/22319
UL http://hdl.handle.net/10347/22319
LA eng
NO Sánchez-Otero, N., Rodríguez-Berrocal, F., de la Cadena, M. et al. Evaluation of pleural effusion sCD26 and DPP-IV as diagnostic biomarkers in lung disease. Sci Rep 4, 3999 (2015). https://doi.org/10.1038/srep03999
NO This research was partially supported by grants PS09-00405 and Research Intensification activity from the Fondo de Investigación Sanitaria (FIS) of the Instituto de Salud Carlos III (Spain) and funding from Xunta de Galicia and FEDER (CN 2011/024). We are grateful to the patients who participated and made the study possible
DS Minerva
RD 25 abr 2026