RT Journal Article
T1 Trace Element Levels in Serum Are Potentially Valuable Diagnostic Markers in Dogs
A1 Cedeño Prócel, Yolanda Mercedes
A1 Miranda Castañón, Marta Inés
A1 Orjales Galdo, Inmaculada
A1 Herrero Latorre, Carlos
A1 Suárez Rey, María Luisa
A1 Luna Narváez, Diego Fernando
A1 López Alonso, María Marta
K1 Dog
K1 Trace elements
K1 Biochemical parameters
K1 Serum
K1 Inductively coupled plasma-mass spectrometry (ICP-MS)
AB The objective of this study was to obtain information about the role of trace element imbalance in the pathogenesis of certain diseases in dogs and to evaluate the suitability of trace element profiling as an additional tool in the diagnosis. Serum trace element concentrations (copper, molybdenum, selenium and zinc) were measured in a cohort of healthy (control) dogs (n = 42) and dogs affected by hepatic (n = 25), gastrointestinal (n = 24), inflammatory/infection (n = 24), and renal (n = 22) diseases. These data were analyzed together with data on basic biochemical parameters (alanine aminotransferase, alkaline phosphatase, blood urea nitrogen, creatinine, albumin, globulin, and glucose) by using chemometric techniques. The chemometric analysis revealed distinctive association patterns between trace elements and biochemical parameters for each clinical disorders. The findings provide clear evidence for the important role of trace elements in disease, particularly in relation to acute phase reactions, with serum copper providing an indirect measurement of ceruloplasmin (positive acute-phase protein) and serum selenium and zinc acting as negative acute phase reactants. Molybdenum may also be a suitable marker of incipient renal disease. Thus, the analysis of trace element profiles, by multielement techniques, in a single serum sample would be a valuable additional tool for the diagnosis of certain diseases
PB MDPI
YR 2020
FD 2020
LK http://hdl.handle.net/10347/24027
UL http://hdl.handle.net/10347/24027
LA eng
NO Cedeño, Y.; Miranda, M.; Orjales, I.; Herrero-Latorre, C.; Suárez, M.; Luna, D.; López-Alonso, M. Trace Element Levels in Serum Are Potentially Valuable Diagnostic Markers in Dogs. Animals 2020, 10, 2316
DS Minerva
RD 24 abr 2026