RT Journal Article
T1 Timing and deciphering mitochondrial DNA macro-haplogroup R0 variability in Central Europe and Middle East
A1 Brandstätter, Anita
A1 Zimmermann, Bettina
A1 Wagner, Janine
A1 Göbel, Tanja
A1 Röck, Alexander W.
A1 Salas Ellacuriaga, Antonio
A1 Carracedo Álvarez, Ángel
A1 Parson, Walther
AB Background: Nearly half of the West Eurasian assemblage of human mitochondrial DNA(mtDNA) is fractioned into numerous sub-lineages of the predominant haplogroup (hg) R0. Severalhypotheses have been proposed on the origin and the expansion times of some R0 sub-lineages,which were partially inconsistent with each other. Here we describe the phylogenetic structure andgenetic variety of hg R0 in five European populations and one population from the Middle East.Results: Our analysis of 1,350 mtDNA haplotypes belonging to R0, including entire control regionsequences and 45 single nucleotide polymorphisms from the coding region, revealed significantdifferences in the distribution of different sub-hgs even between geographically closely locatedregions. Estimates of coalescence times that were derived using diverse algorithmic approachesconsistently affirmed that the major expansions of the different R0 hgs occurred in the terminalPleistocene and early Holocene.Conclusion: Given an estimated coalescence time of the distinct lineages of 10 – 18 kya, thedifferences in the distributions could hint to either limited maternal gene flow after the Last GlacialMaximum due to the alpine nature of the regions involved or to a stochastic loss of diversity dueto environmental events and/or disease episodes occurred at different times and in distinctiveregions. Our comparison of two different ways of obtaining the timing of the most recent commonancestor confirms that the time of a sudden expansion can be adequately recovered from controlregion data with valid confidence intervals. For reliable estimates, both procedures should beapplied in order to cross-check the results for validity and soundness.
PB BMC
SN 1471-2148
YR 2008
FD 2008
LK http://hdl.handle.net/10347/22764
UL http://hdl.handle.net/10347/22764
LA eng
NO Brandstätter, A., Zimmermann, B., Wagner, J. et al. Timing and deciphering mitochondrial DNA macro-haplogroup R0 variability in Central Europe and Middle East. BMC Evol Biol 8, 191 (2008). https://doi.org/10.1186/1471-2148-8-191
DS Minerva
RD 28 abr 2026